Viglast a selective serotonin reuptake inhibitor is a new chemical entity for the treatment of premature ejaculation. Since no systematic studies on design and development of Viglast hydrochloride tablets are available in literature, we propose to develop a suitable formulation to characterize in vitro release profile of Viglast hydrochloride. The aim of the present study was to formulate various formulations of immediate release tablets of Viglast Hydrochloride using different excipients by direct compression and wet granulation method. The granules and tablets of Viglast HCl were evaluated for various pre and post compression parameters like Angle of repose, Compressibility index, Hausner's ratio, Tablet hardness, Thickness, Friability, and chemical parameters. Punches of different size were used to obtain the desired shape, ease of swallowing of tablets, to improve aesthetic value in terms of appearance and shape of tablets. To match dissolution profile of test formulation with innovator, drug particle size is reduced from D 90-158 µ to D 90-45 µ, which resulted in an increased surface area exposed to the dissolution medium. Final formulation was evaluated for multimedia dissolution in three different media and dissolution data was found satisfactory. Accelerated stability studies conducted for 2 Months at 40°C and 75% RH and were found within specification.
Other names for this medication:
Dapoxetine,
Actinex,
Aczone,
Dapoxetin,
Dapoxetina,
Dapsone,
Dejac,
Duraject,
Duralast,
Poxet,
Priligy,
Viglast,
Westoxetin,
Xydar,
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Systemic lupus erythematosus and antiphospholipid antibody, often rifafour treatment for prostate identified in patients with systemic lupus erythematosus, are associated with poor pregnancy outcome. NVs can be used as biomarkers for diagnosis, monitoring of therapy and drug delivery system. We reared green turtles (Chelonia mydas) and loggerheads (Caretta caretta) from hatchlings to 13 weeks of age and documented that they grew wider faster than they grew longer.
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7-Ethoxycoumarin O-deethylation activity, mediated predominantly by CYP 1A1/1A2 but also by other CYPs, was increased after 24h with PB. The Ag-NCs-based 625 augmentin suspension approach provides a novel avenue to detect miRNA with high sensitivity and selectivity while avoiding laborious label and signal amplification. To determine how expression of various immunological determinants affected protection, mice were immunized with recombinant vaccinia viruses expressing different portions of the F-MuLV envelope protein, and they were then challenged with a lethal dose of Friend virus complex.