on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)

Trican (Fluconazole)

Trican is a member of the triazole family, one of the most widely used antifungal agents. It is an FDA-approved drug to treat vaginal candidiasis, oropharyngeal and esophageal candidiasis, Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, disseminated candidiasis, and pneumonia, and cryptococcal meningitis, Prophylaxis is also known to decrease the incidence of candidiasis in patients undergoing bone marrow transplantation who receive cytotoxic chemotherapy and/or radiation therapy. Non-FDA-approved uses for Trican include blastomycosis, histoplasmosis, and coccidioidomycosis. Recently, there has been an increase in the administration of Trican to treat coccidioidomycosis inflicted bone and joint infection, meningitis, pneumonia in immunocompromised patients and pneumonia as a primary infection in HIV positive or severely debilitated patients.

Other names for this medication:
Fluconazole, Diflucan, Afumix, Afungil, Batacan, Candidin, Diflazon, Difluzol, Difluzole, Dizole, Dofil, Duracan, Efac, Elazor, Exomax, Farzul, Fluc, Flucomed, Flucon, Fluconapen, Fluconazol, Flusenil, Flutec, Fluvin, Fluzol, Fluzole, Fluzone, Forcan, Govazol, Honguil, Ibarin, Kifluzol, Lavisa, Logican, Lucon, Medoflucon, Novacan, Omastin, Ozole, Ponaris, Rifagen, Sacona, Stabilanol, Syscan, Ticamet, Trican, Triflucan, Trizol, Uzol, Varmec, Zemyc, Zolax, Zoldicam, Zolen, Zoloder, Zucon,

Similar Products:
Loric, Tensen, Ansial, Finpecia, Filibuvir, Klindan, Micoral, Propecia, Calutide, Kepinol, Lansacid, Uroxacin, Gloclav, Pepticum, Ketilept, Neosar, Ziprax, Mitil, Linaris, Atoksilin, Kefurox, Ketasma, Ambigram, Sefdin, Bimoxyl, Prednisolone, Ometac, Epleptin, Gordius,

trican well servicing canada

Laparoscopic excision of these masses is justifiable, safe and feasible. Next-generation sequencing technologies have expanded the experimental possibilities for studying the genome-wide regulation of transcription by nuclear receptors, their collaborating transcription factors, and coregulators. Duodenal biopsy for diagnosis of renal involvement in amyloidosis. Trajectories of pragmatic and nonliteral language development in children with autism spectrum disorders.

trican buy out contract

Treatment for patients with calcified coronary arteries is troublesome. The transformation is a highly nonlinear dynamical process that involves both pre- and post-synaptic mechanisms. In-gel hybridization with digoxigenin (DIG)-labeled probes has been shown to detect complementary DNA sequences in dried agarose gels.

trican well service ltd email in canada

Adolescent religious commitment and their consumption of marijuana, cocaine, and alcohol. Dissolution rate of commercial dosage form of quinidine sulfate.

trican canada coil tubing company

Control of IFN-alphaA by CD73: implications for mucosal inflammation. High-mobility field-effect transistors from large-area solution-grown aligned C60 single crystals. We studied mercury concentrations in paired bloodspots and cord blood from a convenience sample of 48 Minnesota women and infants.

trican canada coil tubing company

We next addressed the interaction dynamics between cytoskeleton and plasma membrane following PAR-2-induced actin stress fiber formation in both cav-1 -/- and wildtype cells. The disappearance half-life of L-valyl-ara-C was 2.2 h in artificial gastric juice, while the degradation of L-valyl-ara-C was negligible in artificial intestinal fluid and also in the supernatant above the Caco-2 cell monolayer during the 2-h incubation. Migraine is an unrecognized risk factor for OMCNP development in adults.

keane frac buys trican canada

Comparison of patient preference for two insulin injection pen devices in relation to patient dexterity skills. In cases where no dental records are available, age estimation may be performed according to epiphyseal union, skeletal elements or diaphyseal lengths. Ablating liver cell-specific interactions through mutation of capsid proteins or chemical means are promising strategies for reducing adenovirus-induced liver toxicity. Report of 81 cases of testicular tumors treated at the Gustave-Roussy Institute from 1944 to 1953 In the case of low charge density polymer, bridging flocculation is the mechanism.

trican jobs australia for foreigners

Liquid jet delivery method featuring S100A1 gene therapy in the rodent model following acute myocardial infarction. Responses were categorised into three categories: patient-centred, product-focused and ambiguous. We assessed the olfactory epithelium for NiSO(4)-induced changes using histology and immunohistochemistry 1-7 days postinstillation and compared results to olfactory bulb ablation-induced toxicity.

trican tablets for jock itch

For each case, controls were selected using incidence-density sampling. Thus, the peptides that are usually used as inhibitors may function as partial agonists. In the present study, an incidence of silent cerebral embolic lesions after TAVI was identified which was significantly higher than that for BV or AVR. Benign seizures associated with mild diarrhea: clinical analysis of 20 cases.

trican well services canada

In Group I, 6 out of 20 patients had recurrence of angina, of whom 3 required urgent coronary angiography and revascularization. Hereditary abnormal transcobalamin II previously diagnosed as congenital dihydrofolate reductase deficiency. In circumstances where regular brushing is performed, no effect of chewing gum was observed on bleeding and plaque scores.

trican trucks for sale

Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond. Data mining of TAK1 expression in PDA patient gene profiling was conducted.

trican well service pty ltd australia news

Reconstruction of full-thickness alar defect by using the turnover nasolabial flap or Pers flap The in vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidants ascorbic acid (AA), gallic acid (GA), butylatedhydroxytoluene (BHT), butylatedhydroxyanisole (BHA) employing 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay, 2,2-azinobis-(3-ethylbenzothiazoline-6-sufonic acid) (ABTS) assay and N,N-dimethyl-p-phenylenediamine dihydrochloride (DMPD) assay. Influence of the energetic pattern of mitochondria in cell ageing.

trican canada salary scale

  • trican jobs australia perth
  • trican canada salary wizard
  • trican calgary tire stores
  • canada trican corporation
  • trican well service reviews
  • trican usa director of operations
  • trican well service in canada
  • michael trican online
  • trican fracking video for children
  • trican for sale
  • trican tablets for jock itch
  • trican frac pump manufacturers
  • trican canada jobs
  • trican canada salary average
  • cbm solutions trican canada
  • trican jobs australia horses
  • trican store
  • toe tapper trican canada
  • trican in canada
  • trican stores
  • trican tire online login
  • trican well service australia
  • trican well services stockhouse canada
  • trican trucks for sale
  • regional tire distributors trican canada
  • trican corporation canada
  • trican powder for sale
  • trican jobs australia wide
  • trican well service ltd email in canada
  • trican company store
  • brett biggs trican canada
  • trican tires online
  • trican stock price today
  • trican jobs australia mining
  • trican tire web order log in
  • trican well service australia news
  • trican tire web order
  • canada trican corporation in pennsylvania
  • trican jobs australia nurse
  • trican well service stock price
  • trican medicine
  • trican canada salary database
  • trican fracking video for kids
  • trican cement pumper prices
  • trican well service australia post
  • trican online ordering
  • trican stock buy or sell
  • trican well services canada
  • trican canada salary range
  • trican canada salary
  • trican canada salary scale
  • trican well service australia immigration
  • trican canada
  • trican well service australia zoo
  • mike baldwin trican canada
  • trican jobs australia melbourne
  • trican jobs australia for foreigners
  • trican tire order online
  • trican well service pty ltd australia flag
  • trican surplus equipment for sale
  • trican online safety class
  • trican well service ltd calgary ab canada

trican stock buy or sell

D609 stimulated FasL-induced cell death in caspase-8-deficient Jurkat cells, indicating that D609 acts downstream of caspase-8. There is a clinical need to predict the probability of cisplatin-induced nephrotoxicity (CIN) in order to make decisions about patient management and relevant preventive measures. The complex refractive index of the soot was deduced by the fixed-point iteration. Since then, he began having shortness of breath on exertion and was treated with medication.

brett biggs trican canada

Effects of a Rebound Exercise Training Program on Aerobic Capacity and Body Composition. In Escherichia coli, DamMT is involved in multiple aspects of DNA maintenance, replication initiation, daughter chromosome segregation, DNA mismatch repair, gene expression control, etc. During 4 trap nights in Jakarta, 4 rodent species (Rattus exulans, Rattus norvegicus, Rattus tanezumi and Mus musculus) and one shrew species (Suncus murinus) were collected. Surprisingly, under septic conditions, PAD4(-/-) mice did not fare worse than wild-type mice and had comparable survival. The practical field applications of these results are discussed.

trican jobs medicine hat

Feline panleukopaenia virus in captive non-domestic felids in South Africa. The consequences of modeling autocorrelation when synthesizing single-case studies using a three-level model. A 58-year-old man with end-stage heart failure caused by cardiac sarcoidosis underwent an orthotopic heart transplant.

canada law trican rosneft

Though some approaches to the care of patients with NCCP have been developed, more work is needed to determine the most effective management techniques for this unique and high-morbidity population. Estrogen receptor studies should be included in evaluating cancers of unknown origin in female patients. Multiple evaluations of the removal of pollutants in road runoff by soil infiltration. This new procedure for an OME model has proved consistently reliable in creating a persistent and long-lasting effusion.

trican store supply warehouse

By FISH analysis, the two tumours showed either a 1R1G1F or a 2R2G signal pattern, indicating rearrangement involving ALK. Kidney diseases are characterized by deterioration of the function of this organ, often leading to irreversible failure, where transplantation is the only alternative to permanent dialysis. The patient underwent partial removal of the infratentorial tumor via open surgery. Special methods are required to analyse such data because repeated observations on any given response are likely to be correlated over time while multiple responses measured at a given time point will also be correlated.

trican supplement for sale

A high concentration of propofol abolished the positive inotropic effect of alpha- but not beta-adrenoceptor stimulation and enhanced the positive lusitropic effect of beta-adrenoceptor stimulation. pylori stimulates gastrin release from canine antral cells in primary culture. Ten normal-hearing subjects with ages between 28 and 38 years took part in the investigations. Human blood mononuclear cells in culture release a factor(s) that markedly enhances eosinophil cytotoxicity. Lipopolysaccharide-induced apoptosis of endothelial cells and its inhibition by vascular endothelial growth factor.

trican tires for sale

Predictive items of 2-year mortality in nonagenarians with cognitive impairment at baseline: the NonaSantfeliu study. Bipolar disorder has been associated with elevated impulsivity - a complex construct subsuming multiple facets. Correlates of objectively measured physical activity in adults and older people: a cross-sectional study of population-based sample of adults and older people living in Norway. Measurements of the air contaminants in the work environment were also carried out simultaneously by personal and area sampling.

canada trican corporation in pennsylvania

Asymmetric reprogramming capacity of parental pronuclei in mouse zygotes. Identification of rice cultivar with exclusive characteristic to Cd using a field-polluted soil and its foreground application. The immunoreactive nerve fibers increased in density and appeared to extend more incisally.

trican tire order online

Since constant sufficient blood level of tacrolimus and sirolimus had never been achieved, a genetic analysis was carried out to clarify drug metabolism. Information on resident and facility characteristics was obtained from MDS and OSCAR records. Thus, a highly degenerate Y chromosome may not be the worst environment in the genome, as is generally thought, but may in fact be protected from the accumulation of deleterious mutations relative to other nonrecombining regions that contain more genes. There is increasing interest in interventions that target diabetes in SMI in order to help to improve physical health and reduce the associated health inequalities. Identification of fluorescent compounds with non-specific binding property via high throughput live cell microscopy.

trican jobs australia immigration

Conversely, Piasy inhibited NFkappaB activity under the same conditions and sensitized keratinocytes to apoptosis induced by TNFalpha and UVB. To determine primary contributors to sagittal balance and establish a predictive equation of sagittal balance in normal asymptomatic subjects. Stress-related genes and proteins were highly expressed in both the transcriptome and proteome of FN-bound organisms, implying that these genes and proteins may play critical roles in the response to adherence. Here we studied the effect of spinal inhibition of CGRP1 receptors on supraspinally organized vocalizations and activity of amygdala neurons.

trican jobs medicine hat

Here, we describe protocols for the cryopreservation and thawing of semen and testicular tissues using a simple liquid nitrogen vapor technique. In recent years, a promising tool has been introduced which allows the co-registration of electroencephalographic (EEG) activity during brain transcranial magnetic stimulation (TMS). The anthropometric evaluation of patient data showed a high rate of growth retardation in children below the age of 5 years.

trican online

aureus isolation from the nose among students in relation to age, gender, and year of the study. Post-translational phosphorylation of the slow/beta myosin heavy chain isoform in adult rabbit masseter muscle.

trican stock blog canada

Human T lymphocytes, bearing T cell receptor (TCR) gammadelta, play an important role in anti-tumor/microbe immune responses. The results indicate that following apparently complete SCGx in the cynomolgus monkey, reduction of adrenergic innervation to the iris as evidenced by pupillary physiology, electron microscopy, TH-IR and CF does not guarantee reduction in adrenergic innervation to the ciliary body and trabecular meshwork. Cytokines in particular, appear to play a key role in energy balance through persistent activation of the melanocortin system and inhibition of the neuropeptide Y pathway. Emissions from landfills are caused mainly by anaerobic biodegradation processes which continue for very long time periods after landfill closure. Electronic health literacy is a multifactorial concept that includes health literacy but also requires technology skills.

trican frac pump for sale

They contribute to increased disability from decreased motor performance, mobility limitations, reduced functional range of motion, loss of function for activities of daily living, and increased pain. The unique method developed in this study for measuring the in vivo elastic modulus of the neck skin is quite effective, and the skin elasticity value obtained using this method is credible. Testing of olfactory thresholds in the clinic is becoming more common, with commercially produced tests now available. A total of 29 patients that were pathologically confirmed subtypes of CUP were included in the study. Several experiments designed to count the number of tryptophan and methionine-containing peptides in the hemocyanin from the whelk Busycon canaliculatum indicate that sequence homology within the polypeptide chain of the mollusc hemocyanins accounts for their large size.

trican well service ltd email in canada

Hierarchical multivariate regression analysis was used to explore the predictive factors related to social function. After image review, autopsy reports and photographs were compared with the images and interpretations to validate the multidetector CT determinations.

trican jobs australia nurse

The study included 126 persons (62 persons with diagnosed recurrent depressive disorders and 64 healthy volunteers). Alcohol habits in Sweden were surveyed in the general Swedish population at four timepoints, in 1997, 2001, 2005 and 2009, using the 10-item AUDIT questionnaire. Neurophysiological studies point to altered cortical neuronal excitability in migraine patients. These data reveal that enhanced Akt signaling promotes the activation of pathways that are important for the production of proteins and nucleic acids. We conclude that although there are minor differences in the concentration of some urinary biomarkers that are dependent upon the time and duration of collection, shorter collection protocols do not influence subsequent interpretation of normalized urinary biomarker data for most biomarkers.

trican powder

Patients were randomly assigned to receive 1, 2, or 3 mg/kg of body weight per day (total doses of 5, 10, or 15 mg/kg, respectively). Poland) and Asia for the commercial fur trade and into Japan as pets. Effect of Xalatan(R) and Cosopt(R) on the vascular tone of quiescent isolated pig ciliary arteries. The rapid changes in nurse education are proceeding within the wider context of developments in adjacent educational fields, which are themselves subject to external influences, and one such development is the accreditation of prior experiential learning (APEL). This method was adapted to the synthesis of the triglyceride and cholesterol regulator drug, fenofibrate, and its (13)C-labeled derivative in good yields from the appropriate CO-precursor.

dale dusterhoft trican canada

To measure the cardiac troponin I (cTnI) concentration in horses and determine whether it could be used in the diagnosis of myocardial disease, as well as determining the association between cTnI and survival. Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort.

reviews of trican well service

To evaluate the effect of the addition of low-dose esterified conjugated estrogens to the conventional dose of raloxifene in the control of climacteric symptoms. To assess vitamin D status and glucose homeostasis in obese Thai children. Contributions of national health conferences to the definition of public environmental and health information policy.

brett biggs trican canada

On electroencephalography, almost continuous left frontocentral/anterior temporal spikes were observed at 3 years of age, which lasted until 6 years of age, when he developed nonconvulsive status epilepticus. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats. Electromyography of the thigh muscles during lifting tasks in kneeling and squatting postures.

trican well service dental plan

Their demographic parameters, family history, clinical features, precipitating factors, severity of weakness, laboratory parameters and rapidity of recovery were recorded. Understanding fetal globin gene expression: a step towards effective HbF reactivation in haemoglobinopathies. Paleopopulation genetics is a new field that focuses on the population genetics of extinct groups and ancestral populations (i.e., populations ancestral to extant groups). Possibly because of earlier detection, patients with T2DM may be at lower risk for advanced stages of colon cancer at diagnosis.

trican well service ltd email in canada

These correlations increased in patients without stereopsis, suggesting that the presence of binocular fusion can partially interfere with the close correlation of these parameters. It is a safe and effective approach for the treatment of congenital heart disease. Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. Fine morphological evaluation of hypothalamus in patients with hyperphagia.

trican stock prices

Phospholipids of human seminal plasma and their role in ensuring fertility To promote positive beliefs among physicians around the AVS, organizations should obtain physician input into the design and implementation of the AVS and develop strategies to mitigate its negative impacts on workload. Model simulations suggest the same conclusion and indicate that the brighter arc is explainable by the presence of a trailing condensation of ice-bearing granules with a rate of volatile production approximately 23 percent of that of the nucleus.

trican coil tubing unit manufacturers

Effects of Practice Conditions and Supplemental Training Method on Cognitive Learning and Interpersonal Skill Generalization. Basing consultation sample size power calculations for primary care studies or sentinel practice-based surveillance in urinary tract infection on routine laboratory submissions is unreliable and will lead to significant overestimation of recruitment rate. Using a retrospective cohort study design, the investigators enrolled a sample composed of subjects having 1 or more implants placed in the posterior maxilla. These in vivo and ex vivo experimental approaches demonstrated that ocular surface toxicity was reduced by using an emulsion instead of a traditional solution and that a CKC emulsion was safe for future ocular administration.

trican canada salary

To investigate the significance of p63 expression in uterine cervical and endometrial cancers. Gap26, a specific Cx43 mimic peptide, attenuated not only morphine antinociceptive tolerance, but also the up-regulation of spinal Cx43 expression, the activation of astrocytes, and N-methyl-D-aspartic acid (NMDA) receptors (NR1 and NR2B subunits), as well as the decreased GLT-1 expression induced by chronic morphine. Using a stable transfectant with high expression of PCFT, physiologic levels of bicarbonate produced potent and rapidly reversible inhibition of PCFT-mediated transport at neutral pH. Most often it was the stapedial head or anterior limb which was absent.

 Show Hide 
keane group buys trican canada 2014-11-23

Because quality of life is a subjective phenomenon it is not easy vadiral 500 mg efectos secundarios to define, as no gold standard exists as to what is a good life. We explore the possibility of a dichotomy in growth within seminoma and the need to identify molecular methods to predict the subset of tumors that behave biologically less aggressive.

canada law trican rosneft 2019-03-29

The cause of death was classified as brain injury in 61 patients, cardiac disorder in 14 and other in 11. Long-term consequences of forced medicine roliten 2mg hydromorphone displacement need further investigations and should include positive aspects in terms of resilience and protective coping strategies. Fracture of femur is a painful bone injury, worsened by any movement. Bilateral patellar tendon ruptures without predisposing systemic disease or steroid use: a case report and review of the literature. Sharps injuries amongst healthcare workers: review of incidence, transmissions and costs.

trican well servicing canada 2019-07-01

Here we report all segmentation steps (selection of the region of interest, filtering, segmentation). The human-derived allelic form encoding the Sdz-resistant enzyme was gabapentin 300 mg tabletki odchudzajace found in T. Mutations in PIK3CA exons 9 and 20 were quantified by pyrosequencing assays. IDC-P is included in a broader diagnostic category of atypical cribriform lesions of the prostate gland.

trican usa jobs 2012-07-04

CKS proteins interact with some CDKs and play important roles in cell division. Malignant potential in unfavorable neuroblastoma (NB) is dependent on an undifferentiated status. The percentage of increase in the specific activity of RNA and protein was venlift od 75 mg msn-06s higher in the cauda epididymidis than in the caput epididymidis.

trican canada investment trust 2014-01-29

Comparing intensive and conventional treatment, no difference in mortality rate could be observed. Despite an ambition from adults with Autism Spectrum Disorder (ASD) to be employed, there are limited opportunities for competitive employment for this group. FB results from three pediatric pulmonology centers in Istanbul were evaluated. Interestingly, pre-inoculation with Pst, but not with Psm, induced a long-distance acquired resistance (LDAR) response, even though locally a typical recamicina 500 mg levofloxacino nombres set of defense responses, including acquired resistance, was activated locally in response to Psm.

trican well services sale 2010-10-04

We treat the color distortion as a semi-parametric model which separates the non-linear color distortion and the linear color shift. LEP peak-to-peak amplitude, latency, and NRS scoring were compared between genders, and correlations between LEP amplitude/latency and NRS scores were assessed. In the fetal liver, LXRalpha-positive macrophages appeared at 12 days and their number pepzol capsule endoscopy peaked at 18 days of gestation.

toe tapper trican canada 2017-03-18

Iatrogenic or fracture-related nerve injury in a supracondylar humerus fracture is a benign condition which may be resolved spontaneously and observation appears to be a good and valuable method for treatment of this complication. Use of less carcinogenic types of coal could translate to a substantial reduction of lung cancer risk. The alpha34 mAb recognized an unglycosylated 34 kDa protein in the outermost of the six layers that comprise egg-jelly. Apparently, the innate immune system can be effectively recruited to kill cancer cells using the bispecific antibody platform and EpCAM targeting. Investigation of the effects of topraz dosage of amoxicillin single-nucleotide polymorphisms in DNA repair genes on the risk of glioma.

trican jobs australia gov 2014-02-27

NdFeB magnets for home and office use may cause interference with cardiac pacemakers and ICDs at distances up to 24 centimeters. Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74. We showed that UCYN-A has a symbiotic association with a unicellular prymnesiophyte, closely related to calcifying taxa present in the fossil record. Bioinformatics analysis revealed that miR-221/222 had the potential to regulate about 70 common target genes and may exert a cooperative effect on regulation and function via Akt signaling acipan injection pathway. Ethical approval was obtained to compare the pressurized metered dose inhaler (pMDI) VC with Trainhaler (TH), a novel pMDI inhalation flow and technique training device, in children with asthma.

trican frac pump for sale 2013-08-09

A case of glutaric aciduria, a recently discovered inborn error of tryptophan-lysine metabolism, is reported. Also, the long-term renal capsule transplants revealed no difference in the amount of smooth muscle in the epidermal growth factor receptor knockout and wild-type bladders. The role of ideational distress in the relation between persecutory zotrole ingredients in benadryl ideations and reactive aggression. Work with different yeast species has uncovered a great number of moonlighting proteins and shown their importance for adequate functioning of the yeast cell. One of these fractions, virtually devoid of RNA polymerase I activity, was found to form a stable preinitiation complex with small DNA fragments containing promoter sequences from the homologous but not the heterologous species.

trican tire online ca 2014-01-14

To evaluate the characteristics of bicyclespoke injuries in a suburban Indian population. The greater absorption of colostral immunoglobulin in neonate calves suckling their dams over bottle-feeding pooled colostrum was studied to determine if age (hours postpartum) at initial feeding, amount of colostrum ingested, or mothering effect of being with the dam were responsible. The relationship of sex steroids to uric acid levels in plasma and urine. Having poor family functioning and self-concept scores indicating high anxiety and low self-esteem at baseline predicted poor 6-month outcomes overall (Bright sulbacin 375 mg amoxicillin Bodies and Clinic Care groups combined).

trican antifungal medicine 2019-07-25

A series of gramicidin S derivatives 4-15 are presented that have four ornithine residues as polar protonated side chains and fexofenadine 120 mg twice a day bid two central hydrophobic amino acids with unaltered turn regions. The main clinical phenomena in acute low back pain (LBP) with radiculopathy are pain and neurological disorders.