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Topirol (Topiramate)
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Topiramate

Topirol is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Topirol antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Literature data on tea consumption and CVD risk factors support that tea consumption reduces some risk factors especially in overweight people and obese subjects. This QOL assessment is important for planning treatment strategies.

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Perception of the Mueller-Lyer illusion in normal and aphasic adults. Indications for implantable cardioverter defibrillators (ICDs) have been widened considerably during the last decade due to the well-documented effect in the heart failure population.

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EDRF-NO production is reduced in IDDM and this reduction correlates with endothelial damage. Effect of heliogeophysical factors on decompensation of the glaucomatous process and vascular permeability in patients with primary glaucoma Preliminary data suggest that a minimalist, individually tailored VH program may be sufficient to prevent voice problems from teaching in healthy student teachers.

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Bovine placental steroid sulphatase: molecular cloning and expression pattern in placentomes during gestation and at parturition. On even surfaces, a packing density less than 0.2 leads to nearly parallel orientation of the alkyl chains on the surface, a high degree of conformational disorder, and no reversible melting transitions. Borreliacidal OspC antibody response of canines with Lyme disease differs significantly from that of humans with Lyme disease. The described method is implemented on a real dataset from which 22 biological samples were obtained along a pH gradient.

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The key question is how to combine the available database information with the experimental data of the current project ensuring that only relevant information is used and a correct structural bias is produced. Bacteriocin-like substance inhibits potato soft rot caused by Erwinia carotovora. Bunge and Sherman presented the first pregnancy resulting from the thawing of cryopreserved sperm in 1953 (Bunge RJ, Nature 172:767-768, 1953). The possible use of the uranyl-labelled antibody method of determining antiplatelet antibodies may in future help to determine the best method of delivering these babies. Updated figures of species richness of Pristimantis among biogeographic regions in Ecuador are also presented.

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The prototype of primary exaggerated startle is hereditary hyperekplexia, a well-studied disorder of the inhibitory glycine receptor and thus of the neuronal Cl- channel. Lead-free (Bi0.5Na0.5)TiO3-based thin films by the pulsed laser deposition process.

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The most commonly used parameters of MWT were the MW frequencies between 30 and 70 GHz and power density up to 10 mW cm(-2). In parallel, an impressive array of molecular mechanisms has been found to mediate the regulation of the protein.

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The release rate of mPEG(45)-PH(15)-PLLA(82) nanoparticles was much faster than that of mPEG(45)-PH(30)-PLLA(82) nanoparticles at pH 5.0. Contribution to the study of the essential oil from Thymus tosevii growing wild in Greece. In previous studies, we reported that the blood glucose levels of mice with type I diabetes mellitus (TIDM) was reduced with orally administered silk gland powder from silkworms transgenic for human insulin-like growth factor-I (hIGF-I).

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Whereas iNOS expression in melanoma and other cancers is associated with poor clinical prognosis, in vitro and in vivo studies suggest that iNOS and NO can have both protumor and antitumor effects. Antidepressant efficacy of agomelatine: meta-analysis of published and unpublished studies. Current clinical practice for patients presenting to the emergency department with a resolved episode of chest pain and no electrographic or biomarker abnormalities is to conduct routine noninvasive testing, in accordance with American College of Cardiology and American Heart Association guidelines.

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Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy. Stimuli appearing in the surround of the classical receptive field (CRF) can reduce neuronal firing and perceived contrast of a preferred stimulus in the CRF, a phenomenon referred to as surround suppression. Hypocholesteremic effect of glutamic acid in the Mongolian gerbil.

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Over two thirds of all diagnoses are coded automatically with high accuracy. Long-term follow-up is recommended because of a significant reoperation and reintervention rate. The present method is also useful in synthesizing various substituted 2-mercapto imidazole heterocycles.

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Our results provide new insight into mechanisms that control limb development and suggest that defects in the formation of N-Myc-dependent interdigital tissue may be a root cause of common syndromic forms of syndactyly. The patients with RA had significantly elevated levels of sIL-2R at baseline compared with age matched healthy controls.

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It seems important not to use mini-slings of the TVT Secur type as they induce a higher rate of prosthetic exposure. The difference of means was not significant a the cases oral contraceptives for a period Of less than six months and cases using the same for more than six months.

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Diversified properties of the residues between P(2) and P(-3) (including P(2) and P(-3)) of the decapeptide (P(4)P(3)P(2)P(1)P(0)P(-1)P(-2)P(-3)P(-4)P(-5)) may contribute remarkable effect to the interactions between the SH3 domain and the decapeptide. caninum DNA in semen with a parasite load ranging from 0.1 to 15.6 (mean 4.4) and 0.1 to 11.1 (mean 4.1) parasites/ml, respectively. Eight patients were female and six were male, and their mean age was 58 years. The thiolate-catalyzed intermolecular crossed Tishchenko reaction: highly chemoselective coupling of two different aromatic aldehydes.

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This review aims to take stock of new indications for vaginal brachytherapy detailing the trials that led to change standards or care. Sequence comparison of different het-e alleles suggested that het-e specificity is determined by the sequence of the WD40 repeat domain. High COMP levels are risk factors for development of RKOA, as assessed by K/L scores. Laparoscopic choledochojejunostomy via PTFE-covered stent successfully achieves internal drainage of common bile duct obstruction. Paliperidone extended-release tablets for the acute and maintenance treatment of schizophrenia.

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Reversible Brr2 inhibition might in part be achieved via an intrinsically unstructured element of the Prp8 Jab1/MPN domain, a concept widespread in biological systems. The number of patients with end-stage renal disease (ESRD) due to diabetic nephropathy (DN) is increasing worldwide.

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On the other hand, all the subpopulations were uniformly resistant to NK activity in vitro. The overexpression of Egr-1 in MA-10 cells caused an approximately 2-fold increase in reporter luciferase activity. Simple and precise technic for the evaluation of proteinograms by paper electrophoresis This study explored whether reduced distractor processing effects can also occur in healthy individuals with high levels of schizotypal personality traits.

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This raises the question of whether the FasL-Fas pathway plays a major role in beta cell death. A general expression for the probability density function P(I) of the intensity of light reflected from a moderately rough surface in the far field is derived by the cumulant expansion of the random variable.

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Menarche and development of the central nervous system controlling the sexual function in girls with severe mental retardation We report here a case of pleomorphic bone sarcoma (pleomorphic/storiform malignant fibrous histiocytoma) with fibronexus junctions arising in the head of the left humerus of a 70-year-old woman.

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Pseudoarthrosis of the left distal tibial metaphysis and subsequent spontaneous resolution of the abnormality occurred in the younger sibling. Radiological and endoscopical examinations revealed characteristic papillary (villous) features simulating either true adenoma or malignant polyp of the antrum. These recommendations include preventative usage, mixture with partner fungicides active against the current pathogen population, alternation in the mode of action of products used in a spray program, and limitations in the total number of applications per season or per crop.

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Displacement measurement that uses transient photoelectromotive force effects in CdTe:V with frequency-modulated lasers. Moreover, mouse gene disruption studies have implicated HIF-2 alpha in embryonic regulation of tyrosine hydroxylase, a hallmark gene of the sympathetic nervous system.

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T1-weighted and dual spin-echo T2-weighted MR images were obtained, and T1 and T2 parametric image maps were created for 20 patients and 12 controls. The small magnitude of the variation in serum periostin levels suggests that the time of day in which the serum periostin measurements are made is unlikely to influence treatment decisions if a specific serum periostin level is used to predict treatment responsiveness. Other substitutions, however, led to much more random distributions of the intermediates containing only one disulfide.

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The objective of this study was to evaluate the value of the extra time and cost required for different levels of data standardisation and the likelihood of researchers to comply with these levels. In this study, we investigated precisely and comprehensively developmental changes in chicken cardiac and slow skeletal muscle TnT isoforms by two-dimensional gel electrophoresis and immunoblotting with specific antisera. Previous eye tracking research on the allocation of attention to social information by individuals with autism spectrum disorders is equivocal and may be in part a consequence of variation in stimuli used between studies. Compound A, characterized by a very high migration in paper electrophoresis was obtained in a pure state by ion-exchange chromatography and shown by m.s.

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The sensitivity varies among the different testing methods and is maximal with ELISA assays. The observed beneficial effect of stobadine indicates its possible application in the preventive and/or therapeutic approach to I/R-induced pathologies. Awareness, treatment and control of hypertension, dyslipidaemia and diabetes mellitus in an Iranian population: the IHHP study. Endovascular therapy for pulmonary embolism: What do we really know? Comparing to the A reference strains (Jeryl-Lynn and S-79), F genotype MuV were mutated on 12 amino acids sites and 27 amino acids siteson on HN gene.

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The holy grail of therapy for age-related macular degeneration is to avoid the development of choroidal neovascularization. In vitro screening of traditionally used medicinal plants in China against enteroviruses. The characteristics of the prototype motor were measured experimentally. Alterations in the cellular membranes of regressing rat corpora lutea.

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Penetrating cardiac injury tends to generally be repaired without cardiopulmonary bypass in the operating room. Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity. Physical methods typically involve contact between an applicator/electrode and tissue and often results in transient subject discomfort. Effect of exercise intervention on changes in free Fatty Acid levels and metabolic risk factors in stroke patients.

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Rats in an experimental group received trials during which 1 flavor (saccharin) was always followed by cyclophosphamide, an immunosuppressive drug, but another (vanilla) was not. Electron microscopy (EM) and lipid membrane studies were performed on selected isolates. They should be taken into account in bacteriological diagnostic and for production of herd specific bacterins.

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Disturbance of cerebral oxygen transport during neurosurgical anaesthesia. The panel concluded that xylene sulfonic acid and alkyl aryl sulfonate hydrotropes are safe as cosmetic ingredients in the present practices of use and concentrations as described in this safety assessment, when formulated to be nonirritating.

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A staged logistic regression approach was used to examine the relative influence of variables associated with in-hospital mortality. These results suggest a role for increased enzymatic degradation of hyaluronan as a function of inflammation during wound repair.

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Another study with large samples should be performed to analyze the interactions among environments-genes. This dramatic effect occurs without any remarkable modification of the flow rate or the packing fraction above the outlet, which are discarded as the cause of the change in the clogging probability. Although the DS-DAT seems to be of value for monitoring the level of discomfort during CPS, the results of this study should be interpreted within the constraints of the limitations, and further research on the psychometric properties of this tool is needed before the DS-DAT can be used in clinical practice. This study demonstrates a novel mechanism in which IGF1 down-regulates E-cadherin expression through the activation of PI3K/Akt/mTOR signaling and the up-regulation of Snail and Slug in human ovarian cancer cells.

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The 2- and 3-bone fusion groups demonstrated increased radial deviation and pure flexion. The value of the computed tomographic obstruction index in the identification of massive pulmonary thromboembolism. Relative to wild-type mice, NMB-R-deficient mice showed decreased marble burying behavior. Incremental diagnostic value of SPET/CT in precise localization of extraskeletal uptake of bone-seeking agents in multiple myeloma. DWI can be used to assess the risk grade of GISTs, but conventional MR imaging is of limited use.

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We found that in patients with advanced MM, MK615 dramatically suppressed the cutaneous in-transit metastasis of the disease. In tissue explants, treatment with the MDM2 inhibitor nutlin-3 induced apoptosis as well as senescence as revealed by a dose-dependent increase of the expression of BAX as well as of p21, respectively. The intracellular antimicrobial activity of LVF-NHs and free LVF was compared on HeLa epithelial cell line infected by the above mentioned bacteria, and the increase in antibacterial efficacy of LVF-NHs with respect to that of free LVF was evidenced. Respiratory infections caused by Chlamydia in an Aranda de Duero health area Poly thymine stabilized copper nanoclusters as a fluorescence probe for melamine sensing.

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A unusually high rate of HCV-infected individuals in whom the HCV genotype cannot be ascertained by means of single PCR and LIPA procedures has recently been reported in our area. Factors affecting circulating growth hormone binding protein in chickens. Comparison of plasmapheresis and molecular adsorbent recirculating system efficacy in graft failure after living donor liver transplantation. Mass measurement accuracy with errors less than 5 ppm is demonstrated on a mixture of 12 peptides ranging in mass from ca.

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CTA is reliable in diagnosing and grading aortic trauma, measuring aortic diameter in aortic aneurysms and detecting vascular wall pathology in acute aortic syndrome and aortic inflammation. A risk-benefit assessment of alendronate in the treatment of involutional osteoporosis.

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Insights into a divergent phenazine biosynthetic pathway governed by a plasmid-born esmeraldin gene cluster. An implantable, batteryless, and wireless capsule with integrated impedance and pH sensors for gastroesophageal reflux monitoring.

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Finally, they raise the possibility that NADPH oxidase may be regulated by the action of GAPs for Rac proteins. Amidines and guanidines are often only thought of as strong organic bases however, a number of small molecules containing basic functional groups have been shown to act as efficient nucleophilic catalysts. We also established the presence of Neu5Acalpha2,3/2,6-Galbeta1,4 GlcNAc-terminated chains on the surfaces of 12-day-old EBs, as indicated by the great enhancement of staining by Erythrina cristagalli agglutinin (ECA) after treatment with neuraminidase.

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Further increase in the agonist level activated the mitochondrial uniporter leading to calcium uptake by mitochondria, which caused the collapse of mitochondrial membrane potential in a fraction of platelets leading to the PS exposure. Glomerular diseases and renal transplantation are the main fields of nephrology in which the immune system plays a prevalent role. These results suggest that B7-H3 may be a promising biomarker and associated with the pathogenesis of MS. Ten of the tumors were clinically radiosensitive and six were radioresistant.

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Children have been called therapeutic orphans as they have been excluded from drug research and new drug development resulting in the lack of proper labels for majority of the drugs for pediatric use. Of therapeutic interest, new strategies for the development of more effective clinical treatments against the locally aggressive and invasive cancers based on the molecular targeting of deregulated signaling elements in tumorigenic and migrating cancer cells and their local microenvironment are also described.

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For sodium salicylate whose hepatotoxicity is unassociated to P450 activities, more significant reductions on cell viability and albumin synthesis at 5 mM than those at 1 mM apparently illustrated the concentration-dependent hepatotoxicities of gel entrapped hepatocytes as well as hepatocyte monolayer. Urticaria pigmentosa---change in conscious state associated with rise in plasma histamine levels. There is an urgent need for participation scales to focus on empowerment as well as collective capabilities.

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Valproic acid (VPA) is an anticonvulsant that is a known risk factor for autism in prenatally exposed children. Thus, these results indicate that Rac1 mediates apoptosis via JNK and plays a key role in proapoptotic pathways in intestinal epithelial cells. Integrated mental health services in a Scottish health district. It was found that, because of the close proximity of the binding energies of paper to paper and of paper to mud, it was difficult to maintain control of the ablation process. Patients eligible for MP from August 2011 to November 2015 were randomized into the RA-MP or OMP group.

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A large portion of meningococcal antigen typing system-negative meningococcal strains from spain is killed by sera from adolescents and infants immunized with 4CMenB. Endometrial adenocarcinoma occurs almost prevacid generic omeprazole name exclusively in postmenopausal women, and excessive or unopposed estrogen stimulation is suspect as a causative factor in its pathogenesis.

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Integer programming-based method for grammar-based tree compression and its application to pattern extraction of glycan tree structures. The changes induced may be modified by norgestrel but not by other available progestagens. It appears the timing of incentive payments does not affect response rates for telephone interview surveys conducted on primary care patients in Hong Kong at baseline or at 1-year follow-up. We characterized the progestogen-induced alterations of gene expression in a human levofloxacin after alcohol abuse endometrial-cancer cell line using a mRNA differential-display reverse-transcriptase-polymerase-chain-reaction (DDRT-PCR) method. The National Network of Congenital Anomalies: extended goals for surveillance.

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Fumonisins: current research trends in developmental toxicology. Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1. IL-1beta, TNF-alpha and C5b-9 are components of SIR and have been speculated to be involved in the clinical brain edema (BE) of DKA. The presence of tooth marks and the lack of hominin-produced bone modifications together argue against hominins as the responsible agents for bone esomeprazole 20 mg ratiopharm zwillinge accumulation and modification. Evaluation of a diagnostic algorithm for sputum smear-negative pulmonary tuberculosis in HIV-infected adults.

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Hypercapnia suppressed the transcription (mRNA) and translation (protein) of the major inducible prostanoid-generating enzyme (COX-2), but the effects on the downstream eicosanoids were modest. Alternative Splicing in Next Generation Sequencing Data of Saccharomyces cerevisiae. Fifteen patients had abnormal CT scans subsequently shown to be a benign process or second malignancy. Evaluation of isometric force in lower limbs and body composition in preterm infants In addition, pX increases the DNA binding fluconazole 200 mg evenement potential of bZip proteins for their cognate DNA-binding site in vitro.

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The use of CBPR omesec omeprazole 20mg capsule principles was a successful way to create mini reports about local lung cancer disparities and risk factors that were usable in individual communities. Rete mirabile associated with pial arteriovenous fistula: imaging features with literature review.

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