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Topiramate is the brand name of Topiramate, an anticonvulsant drug used to prevent seizures and reduce the frequency of migraines. While its exact mechanism of action is unknown, studies suggest Topiramate might alter the production or action of neurotransmitters in the brain, suppressing the abnormal activity of the nerves in the brain that cause seizures or preventing the abnormal activity from spreading to other nerves. Other research has suggested that it might suppress the nerves directly, thereby making them less likely to fire. The Food and Drug Administration (FDA) approved Topiramate to treat seizures in 1996.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Perimetric isopters for varying degrees of color saturation were determined by kinetic perimetry. Monitoring specific quality indicators ensures safe delivery of epidural analgesia and evaluates the effectiveness of the pain management program. The end goal is to identify clinically significant alloantibodies in order to provide antigen negative, compatible red blood cells, which reduces the risk of transfusion related reactions. We sought to investigate neurotoxicity in vitro and block duration in vivo in a genetic animal model of diabetes mellitus type 2. The psychometric properties of the Dutch PACIC and PACIC-S were satisfactory and it is sensitive to change, rendering it a valid and reliable instrument for assessing chronic illness care among CVD patients.

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A PCR study of piroplasms in 166 dogs and 111 horses in France (March 2006 to March 2008). When the pH of the fermentation system was controlled at higher levels, it was found that sugars utilization was facilitated, but less butanol was produced due to the over-accumulation of organic acids. Pharmacological treatments for fatigue associated with palliative care Reciprocal transformation experiments provided further evidence consistent with functional changes in both cis and trans regulation of lin-11. Selection, consumption, and waste of apples were measured prior to and during treatment.

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Inhibition of epithelial-mesenchymal transition in A549 cell by transfected Napsin A. Endothelial dysfunction and inflammation in different stages of essential hypertension. Analysis of erectile responses to BAY 41-8543 and muscarinic receptor stimulation in the rat. Socially reinforced obsessing: etiology of a disorder in a Christian Scientist.

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The distribution of this compound in liver of rats treated with CCl4 (25-100 microL/100 g body weight) was more than five times higher than that of non-treated rats, corresponding to the accumulation of Evans Blue, a marker dye for capillary permeability. These data were thoroughly analysed and interpreted with inspiration from the French philosopher, Paul Ricouer. When neurologic findings are remained after air embolism, hyperbaric oxygen therapy should be arranged immediately.

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This Minireview discusses the most recent progress in heterogeneous manganese-oxide-based catalysts for efficient chemical, photochemical, and electrochemical water oxidation as well as the structural requirements for the catalyst to perform actively. Incorporation of r-chagasin into an artificial diet system at 0.1 g kg(-1) retarded growth rate, decreased larval survival and led to complete mortality of A.

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Effect of Process Temperature on Virus Inactivation during High Hydrostatic Pressure Processing of Contaminated Fruit Puree and Juice. In asthma, however, there is a complex relationship between ASM and inflammatory cells, such as mast cells and T lymphocytes.

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Disease Activity Score 28-ESR bears a similar relationship to treatment decisions across different rheumatologists, but misclassification is too frequent to replace physician judgement. Emerging concepts in high-impact publishing: insights from the First Brazilian Colloquium on High Impact Research and Publishing.

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Insulin sensitivity in non-diabetic relatives of patients with non-insulin-dependent diabetes from two ethnic groups. Ultrasound and Radiographic Abnormalities in a Patient With Chronic Severe Acromegaly. In the case of NF-kappa B p50, S-nitrosylation resulted in significantly decreased DNA binding. A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network. It affects single cells and is correlated with characteristic morphological and biochemical changes.

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Serum calcium screening on admission to the department of internal medicine We also show that degradation of TMAP/CKAP2 during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 and that the KEN box motif near the N terminus is necessary for its destruction. We have recently shown that treatment with the calcium channel blocker nitrendipine may aggravate albuminuria and glomerular injury in rats with two-kidney, one clip renovascular hypertension if arterial blood pressure is not reduced.

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Bevacizumab, a monoclonal antibody that binds to the vascular endothelial growth factor (VEGF) has been linked to PRES. Time-of-flight mass spectra obtained for strong-field ionization using simply a transform-limited femtosecond laser pulse allows for quantitative characterization of the composition of an unknown mixture, including determination of isomeric composition. We explore the trends in the height of recruits by religion and place of birth. Incident dementia was associated strongly with age and current level of cognitive performance, but not with rate of decline.

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Thus, our results suggest a previously unknown Stat3-Skp2 molecular network controlling cervical carcinoma development. This paper addresses the question of the coordination environment of copper (II) in hair.

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To show the eventual presence and extent of production of matrix metalloproteinase 13 (MMP-13, or collagenase 3) in rheumatoid synovial tissue samples and extracts, and to assess the inhibition characteristics of recombinant MMP-13. Experimental study on the induced-differentiation of human esophageal cancer cells treated with dimethylsulfoxide Reliable characterization of locomotor dynamics of human walking is vital to understanding the neuromuscular control of human locomotion and disease diagnosis. F-actin disruption revealed that relocalization and assembly of F-actin at the ends of cellular extensions were necessary for NGF-induced tau reorganization and association with actin.

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Self-reported differences on measures of executive function and hypersexual behavior in a patient and community sample of men. We describe two cases of pulmonary arterial hypertension (PAH) that occurred under dasatinib treatment and were resolved after dasatinib discontinuation. The use of sighting records to infer species extinctions: comment. Differential coherent demodulation based on synchronous sampling yields a signal-to-noise ratio (SNR) of about 54 dB .

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The aim of this study was to assess the validity of Narhinel method in the prevention of recurrences of viral rhinitis and of any associated sequelae, in particular acute otitis of the middle ear (AOM) and acute rhinosinusitis (AR). Two overnight study periods were scheduled at the CRC at least one week, but not more than two weeks apart. Improved fat water separation with water selective inversion pulse for inversion recovery imaging in cardiac MRI. A polymer/oil based nanovaccine as a single-dose immunization approach.

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This paper provides a comprehensive review of the application of bioactive ceramics for bone repair and regeneration. The heart is one of the major organs involved in scleroderma, the involvement of which can be manifested by myocardial disease, conduction system abnormalities, arrhythmias, or pericardial disease. Effects of differential interference with postnatal cerebellar neurogenesis on motor performance, activity level, and maze learning of rats: a developmental study.

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The life expectancy of mice, who were exposed to skin burns in different time intervals previous and following whole body irradiation The characterization of leukemia-specific antigens eliciting immune responses in the autologous host has prompted researchers and clinicians to broaden the spectrum of dendritic cell vaccines to hematological malignancies. Administration of indomethacin may aid treatment of intracranial hypertension, and the present study was conducted to determine the optimal dose.

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The nanofibers were obtained with chitosan in shell while poly(lactic acid) in core attributing to phase separation, which were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy dispersive spectrometer (EDS). There is little clinically significant night-to-night variability in pediatric polysomnography, and no first-night effect. On the spectrum of ergot alkaloids contained in the sclerotia of Claviceps purpurea (Fr.) Tul. Therefore, the enhanced delivery of PTNP appears to be mediated by both passive accumulation to angiogenic regions and active recognition by endothelial cells. Modelling lead bioaccessibility in urban topsoils based on data from Glasgow, London, Northampton and Swansea, UK.

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This would require involving all local stakeholders to discuss feasible and acceptable solutions. The dual-process theory of cognition (system 1 non-analytic and system 2 analytic processes) and the metacognition theory are used to develop an integrated model of clinical reasoning.

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The role of Hh signaling has been studied in several xenograft tumor models, however, the role of Hh in tumor development in a transgenic prostate cancer model has never been examined. The protective effect of ambroxol, a mucolytic agent which has antioxidant properties and stimulates the release of pulmonary surfactant, against influenza-virus proliferation in the airway was investigated in mice.

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Comparison of the Sit-to-Stand Test with 6 min walk test in patients with chronic obstructive pulmonary disease. Histochemical investigation on the mechanism of action of a synthetic mucolytic compound (Na 872 Cl): preliminary results

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Collaborating with nonphysician professionals in practice-based research. Disorders of microcirculation in diffuse toxic goiter and their correction in the early postoperative period Phylogenetic analysis by using sequence fragments of the D2 domain did not allow to perform phylogenetic inferences on species within the brasiliensis complex, because the gene alignment composed of a matrix with 37 specimens exhibited only two variable sites along the 567 base pairs used. In addition, one patient developed grade 3 central nervous system toxicity in cycle 2 (not a DLT).

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A simple method for the determination of Bosutinib in rat plasma by UPLC-MS/MS. Head group modulated pH-responsive hydrogel of amino acid-based amphiphiles: entrapment and release of cytochrome c and vitamin B12. In one of these families, inheritance appeared to occur in an autosomal recessive manner, whereas in the other, autosomal dominant expression seemed evident.

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Other data suggest parasitic infections may induce allergic responsiveness. The gamma-herpesviruses maintain latent infection in restricted subsets of hematopoietic cells as a result of an intricate balance between host factors that suppress infection and viral factors that facilitate evasion of the immune response. We describe a case of a 41-year old woman who presented with the classic signs and symptoms of superior vena cava syndrome. Translational and transdisciplinary research is needed to tackle complex public health problems. Insertion of the immunoaffinity step in our purification procedure made the purification of human DNase II easier, faster and more effective than the conventional procedure.

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The importance of conduct problems and depressive symptoms in predicting adolescent substance use. Under other stress conditions including low phosphorus nutrient, drought and high temperature, the nla mutant did not show this early senescence phenotype, but closely resembled the wild type in growth and development. Surface runoff and subsurface tile drain losses of neonicotinoids and companion herbicides at edge-of-field.

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With the advent of transesophageal echocardiography and magnetic resonance velocity mapping, further evidence of the presence of secondary flows even in the descending aorta has been reported. Poly (2-ethylacrylic acid) (PEAA) alkylamide derivatives were synthesized for constructing pH-sensitive liposomes by partially modification of carboxylic groups of PEAA with chemical reaction. An association between pulmonary hypertension and impaired lung function in infants with congenital diaphragmatic hernia. The aim of this study was to investigate the roles of protein kinase A (PKA), protein kinase C (PKC), protein tyrosine kinase (PTK) and intracellular calcium in the induction of IL-8 production by gastric epithelial cells. The reflected horizontal and vertical polarization light rays are delivered via an optical switch to a single spectrometer by turns.

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Self-defense mechanisms developed by microalgal cells to survive in metal-containing media and environmental factors that affect their removal (e.g., pH, temperature, and biomass concentration) are reviewed here in a comprehensive way and further discussed in attempts to rationalize this form of remediation vis-a-vis with conventional nonbiological alternatives. The angiogram performed 1.5 hours after milrinone administration displayed resolution of the CT angiogram and MRI based cerebral vasospasm such that further intra-arterial therapy was aborted. Malfunction of the inner ear is the most frequent cause of dizziness The epidemiological risks associated with these changes in eating patterns should not be incorporated into a reliable economic instrument.

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We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1. The combination of these techniques with high-resolution imaging tools and molecular perturbations will lead to a better understanding of the mechanisms underlying collective cell migration in health and disease.

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Sleep-related complaints are common in adolescents, but their impact on the rate of motor vehicle crashes accidents is poorly known. A 46-year-old man suffered rheumatoid arthritis and underwent HD at local HD center.

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A descriptive and analytical survey was conducted in the Kunming Medical University hospital among patients over 60 years of age, hospitalized with AECOPD, between March 2007 and June 2008. While topographical differences emerged, there were no significant global differences between AD/HD types in girls.

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Blastomeres 1q(221) and 1q(212) locate at the same equatorial latitude after the complementary asymmetric division of their 1q(22) and 1q(21) precursors. We report our experience with the use of expandable cages in this subgroup of patients.From August 2006 to May hiconcil 500 mg krkavec 2008, 5 patients presenting with myelopathy, pain, and/or radiculopathy secondary to metastatic disease of the cervical spine underwent multilevel cervical corpectomies and placement of expandable cages in our institution. Our data demonstrated that PQ-induced IL-6 expression in macrophages plays a central role in pulmonary fibrosis through enhanced epithelial-to-mesenchymal transition (EMT). Population-based prospective cohort study of 246,361 individuals aged greater than or equal to 45 years, from New South Wales, Australia, recruited from 2006-2009. Treatment of total-body x-irradiated monkeys with autologous and homologous bone marrow.

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Molecular recognition of melamine by vesicles spontaneously formed from orotic acid derived bolaamphiphiles. Inclusion of NPs in the NICU care team enhances the care provided to infants and their families. In hypothalamic nuclei, estradiol increases L-PGDS transcript expression, whereas in the ventrolateral preoptic area L-PGDS gene expression is reduced after fexofenadine generic names estradiol treatment.

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Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms. Among these are prolymphocytic leukemia (PLL), hairy cell leukemia (HCL) and its variants, large granular lymphocyte leukemia (LGLL) and adult ketoconazole 200 mg tablets side effects T-cell leukemia/lymphoma (ATLL). Laparoscopic mobilization of the right or left hepatic lobe is performed, including dissection of the round, faliciform, triangular, and coronary ligaments. Our study showed that CERA may be more effective than DA for management of anaemia during the predialysis period in CKD patients.

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Identification of a point mutation associated with a silent phenotype of human serum butyrylcholinesterase--a case of familial cholinesterasemia. The lack of cytokines suggests injectate-related changes rather than mechanical trauma. Pharmacokinetics of temozolomide given three times a day in pediatric and adult cefixime syrup san bernardino county patients. Fifteen articles on systematic evaluation of both English and Chinese were retrieved and studied carefully, their basic information was analyzed.

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