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The identification of a growing number of transcription factors with enzymic activity suggests that such dual-function proteins exert greater control of signaling events than previously imagined. Over a 2-month period, a 34-year old man with phimosis developed a pedunculated tumor, measuring 4 X 2.5 X 2 cm in his glans penis. Carboplatin/5-fluorouracil as an alternative to cisplatin/5- fluorouracil for metastatic and recurrent head and neck squamous cell carcinoma and nasopharyngeal carcinoma.

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Better understanding of the genetics of inherent and acquired resistance is needed to guide development of second-generation agents. Analogy in the adsorption of random copolymers and homopolymers at solid-liquid interface: a Monte Carlo simulation study. Iron isotopic fractionation between silicate mantle and metallic core at high pressure. Many questionnaires have a high number of items and complex rating scales.

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Long-term demographic analysis in goshawk Accipiter gentilis: the role of density dependence and stochasticity. The Nash-Sutcliffe efficiencies of the models ranged from 0.61 to 0.88, and they adequately captured the upstream boundary, tributary, and stormwater concentrations.

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TCs have small cell bodies, and remarkably thin, long, and moniliform prolongations called telopodes (Tps). Exploration of the counseling needs of infertile couples: A qualitative study. Both the Ad12 and Ad5 peptides dissolved in trifluoroethanol/water mixtures were found to adopt regular secondary structural conformations seen as a series of beta-turns. This cyclic urethane technique (CUT) also provides a general strategy for synthesis of C-terminal protected peptides that can be used for convergent synthesis of large peptides.

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Fluorophotometric study of the effect of the glaukos trabecular microbypass stent on aqueous humor dynamics. Failure of regulatory mechanisms of the intestinal flora could therefore play an important role in the pathogenesis of gut-derived infections. The study highlighted the importance of the wrists in generating club head velocity and orienting the club face. The relationship and cross-talk among these cells determine gene expression, phenotypic distinction, and ultimately whether endothelial cells survive, proliferate, or undergo apoptosis.

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Time-resolved laser fluorosensors: a laboratory study of their potential in the remote characterization of oil. Pharmacoepidemiology of benzodiazepine and sedative-hypnotic use in a Canadian general population cohort during 12 years of follow-up. Isolated ventricular myocytes were preconditioned either by metabolic inhibition or with U50,488H, a kappa-opioid receptor agonist. Although nonactivated primary T cells cultured with 10 to 1000 nM TCDD were relatively resistant to apoptosis, they became sensitive to apoptosis upon activation with concanavalin A (ConA).

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These findings suggest that patients with PEComas may require whole-body follow-up examinations because different subtypes of PEComas may occur multifocally. Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys: a behavioral economic analysis. We have observed that preassembly of AL does not inhibit the formation of a double membrane surrounding sperm chromatin. Specific inspiratory threshold loading training alone, or combined with specific expiratory training, markedly improved respiratory muscle strength and endurance in patients with MG. In this review, the authors examine integrin signalling and integrin-GTPase interplay in the context of cancer cell growth and behaviour.

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Animals-31,671 cats vaccinated in the United States and Canada by veterinarians with World Wide Web access. Microbial biodegradation of 2,4,5-trichlorophenoxyacetic acid and chlorophenols. We have previously shown, in an in vivo model of experimental PH, that mesenchymal (interstitial) fibroblasts and intermediate cells are the progenitors of these cells.

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The effect of the form and level of nitrogen in the diet for sheep on ammonia content in the rumen gases and surrounding air. Robot-assisted laparoscopic resection of large retroperitoneal paraganglioma - initial experience from China.

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Reporter assays showed that MT regulated the OPN promoter through two of its PEA3 (polyoma enhancer activator 3) sites. Furthermore, a treatment regimen for cancers of rare histological types has not been established. High dietary cholesterol and ovariectomy in rats repress gene expression of key markers of VLDL and bile acid metabolism in liver. Effects of ergocornine and prolactin on aggression in the postpartum golden hamster. Clustering of at least three of these factors in an individual is defined as metabolic syndrome (MetS).

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The purpose of this study was to develop a scalable, robust, and reproducible process to derive purified cardiomyocytes from genetically engineered embryonic stem (ES) cells. Glucocorticoids play a critical role in normative regulation of fetal brain development.

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We assessed expression of cyclin D1 in surgical specimens of breast carcinoma by means of immunohistochemistry. Here, we focus on the spatiotemporal regulation of DNA replication in the human genome.

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In conclusion, OsRab11 may be required for JA-mediated defense signaling by activating the reducing activity of OsOPR8. Concomitant radiotherapy with mitomycin C and bleomycin compared with radiotherapy alone in inoperable head and neck cancer: final report.

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Our findings support a novel concept in vascular biology that fibroblasts in the adventitia may play a role in the regulation of vascular tone after successful transfer and expression of recombinant eNOS gene. We further established a novel in vitro model of antiandrogen-resistant prostate cancer (LNCaP-BC) by long-term bicalutamide treatment. Availability and consumption of opioids have increased and opioids other than morphine (including methadone, fentanyl, oxycodone) have become more widely used. Typhimurium-induced NF-kappaB activation, and IL-8 production, and lowered the phosphorylation of both Akt and p38. Conservative treatment of ulcer perforation with constant suction drainage

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Diurnal variability of pharmaceutical, personal care product, estrogen and alkylphenol concentrations in effluent from a tertiary wastewater treatment facility. Because student attitudes about prevention counseling are influenced by personal eating habits, this suggests that students with a more healthy diet will be more likely to recommend the same for their patients. Ureteral reimplantation (4 ipsilateral and 3 contralateral) was performed only after urodynamic abnormalities were addressed. Exercise renography was normal in 12 patients, while in 3 patients minor abnormalities were observed during exercise related to a minimal degree of pelvic dilatation.

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Use of 504 plans for children and youth with disabilities: nursing application. The original compensator set can be used together with a few field-in-field (FiF) beams defined by the MLC (or beams with cerrobend blocks for accelerators not equipped with a MLC). Origin of the genetic code: first aminoacyl-tRNA synthetases could replace isofunctional ribozymes when only the second base of codons was established. In practice, families stay in a standard interim solution for months or even years while trying to return to their routines.

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To investigate if the p33ING1 isoform is also involved in chemosensitivity, we overexpressed p33ING1 in melanoma cells and assessed for cell death after treatment with camptothecin. An expert system of diagnosis of the immune disorders types according to Gell and Coombs classification was for the first time applied in the examination of 63 patients with different forms of an acute pancreatitis (AP).

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Rectal hydrocortisone during stress in patients with adrenal insufficiency. A simulated data set is used to show that small focal differences in thickness between two groups of subjects can be detected. The Psychometric Latent Agreement Model (PLAM) is proposed for estimating the subpopulation membership of individuals (e.g., satisfactory performers vs.

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Signalled reinforcement in differential-reinforcement-of-low rate schedules. To investigate current nutrition counselling practices, knowledge of nutrition and the need for nutrition education by nurses in mother and child health clinics. After exposure, most of the DEHP is rapidly metabolised to mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), which may be associated with reproductive hormone interruption and testicular toxicity. Effects of CDNF on 6-OHDA-induced apoptosis in PC12 cells via modulation of Bcl-2/Bax and caspase-3 activation.

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Waveguiding properties of (Se,S)-based chalcogenide glass films and some applications to optical waveguide devices. Axonal damage is a particularly important component of the pathology of multiple sclerosis and appears to be a critical determinant of clinical outcome.

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Other differences, attributable to utility formula, are comparatively unimportant. Novel tyrosine kinase signaling pathways: implications in vascular remodeling. These data suggest that activation of cell-mediated immunity is part of the early host response to leptospirosis.

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Midkine (MK) is a heparin-binding growth factor that is overexpressed in various human cancers. Gene flow FST estimates indicated homogeneity in the studied population, with limited population substructuring, but with a tendency of sand fly vectors to form clusters by micro-habitat (domestic and peridomestic). This study demonstrates that it may be possible to predict the clearance of CYP1A2 substrates in smoking populations using quantitative estimates of CYP1A2 abundance based on daily cigarette consumption in conjunction with an IVIVE approach. We propose that these bacterial proteins mimic molecular markers of self-surfaces, providing a compelling hypothesis for how FH prevents complement-mediated injury to host tissue while lacking efficacy on virtually all other surfaces.

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The current study had two goals: in a first experiment we investigated whether these differences were stable across time, using the parallel form method often used in psychometric research, and in a second experiment we investigated whether the individual differences in categorization strategy were related to working memory capacity. To determine the effects of training and sustained submaximal exercise on hematologic values in racing sled dogs. Correlation ranking-principal component regression and correlation ranking-principal component-artificial neural networks were applied in constructing predictor models.

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The IR group had significantly elevated tissue SOD activity, GSH-Px activity, and MDA levels compared with the sham group. The alpha-herpesvirus, equid herpesvirus-1 (EHV-1), causes single or epizootic abortions or neonatal deaths in equids, and the closely related virus EHV-4 causes sporadic equine abortions. Our findings support a protective effect of bisphosphonates against colorectal cancer.

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Selection of carotid artery stenting or endarterectomy based on magnetic resonance plaque imaging reduced periprocedural adverse events. Nasal dermoid cyst with a sinus tract extending to the frontal dura mater: MRI. dorsalis males are not only attracted to, but also eagerly consume (up to approximately 1 mg/insect) compound I, thus recognizing this fluorinated benzene as a close kin of the natural ME.

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Diagnosis of congenital and chronic acquired toxoplasmosis in patients with endocrine disturbances should be based on the results of complex clinico-roentgenological and laboratory studies. Taken together with previously reported BAD1 perturbations of TNF-gamma and TGF-beta, these data suggest that BAD1 contributes significantly to the pathogenicity of B. Consequently, attempts have been made to reduce the SNS hyperactivity, in order to intervene early in the course of the disease and prevent HTN-related complications later in life. Here, we report that Ang-1 appears important in normal murine lung development, and have established its tissue-level expression and localization patterns at key time-points. Of the 50 cases, nine presented other features (pectum excavatum, cleft palate, mental retardation, ulnar agenesis, etc.).

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A 47-year-old partially edentulous woman received two experimental implants along with conventional implant therapy. A principal function of the microbiota is to protect the intestine against colonization by exogenous pathogens and potentially harmful indigenous microorganisms via several mechanisms, which include direct competition for limited nutrients and the modulation of host immune responses.

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Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. The study of gene regulation has rapidly advanced by leveraging next-generation sequencing to identify and characterize the cis and trans elements that are critical for defining cell identity. Pediatric brain tumors in Nigeria: clinical profile, management strategies, and outcome. Time-frequency heart rate variability characteristics of young adults during physical, mental and combined stress in laboratory environment.

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In addition, there is some question whether the pituitary-adrenal system can be conditioned in a Pavlovian sense. The experimentation results validate the effectiveness of the proposed controller. The purpose of this article is to bring some of the potential causes of false-positive and false-negative interpretations of dural sinus thrombosis (DST) on cross-section imaging studies to the attention of radiologists.

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A GST preparation from mouse liver also metabolized most of our pyrethroid-like substrates with both chemical and geometric preference but at 10- to 170-fold lower rates. Infections associated with intra-spinal catheter-pump systems for severe pain management.

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Of the large variety of reconstructive procedures, this article discusses those techniques that are used routinely. The recommended regimen for SCIT is a gradual updosing over a period of weeks. The mean width at the most superior aspect of the insertion site was 1.8 cm (range, 1.5 to 2.6 cm). It is often described as cystic mass with or without solid component, difficult to distinguish from hepatic abscess, hematoma, cystoadenoma or malignant neoplasia.

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