Dapsone a selective serotonin reuptake inhibitor is a new chemical entity for the treatment of premature ejaculation. Since no systematic studies on design and development of Dapsone hydrochloride tablets are available in literature, we propose to develop a suitable formulation to characterize in vitro release profile of Dapsone hydrochloride. The aim of the present study was to formulate various formulations of immediate release tablets of Dapsone Hydrochloride using different excipients by direct compression and wet granulation method. The granules and tablets of Dapsone HCl were evaluated for various pre and post compression parameters like Angle of repose, Compressibility index, Hausner's ratio, Tablet hardness, Thickness, Friability, and chemical parameters. Punches of different size were used to obtain the desired shape, ease of swallowing of tablets, to improve aesthetic value in terms of appearance and shape of tablets. To match dissolution profile of test formulation with innovator, drug particle size is reduced from D 90-158 µ to D 90-45 µ, which resulted in an increased surface area exposed to the dissolution medium. Final formulation was evaluated for multimedia dissolution in three different media and dissolution data was found satisfactory. Accelerated stability studies conducted for 2 Months at 40°C and 75% RH and were found within specification.
Other names for this medication:
Dapoxetine,
Actinex,
Aczone,
Dapoxetin,
Dapoxetina,
Dapsone,
Dejac,
Duraject,
Duralast,
Poxet,
Priligy,
Viglast,
Westoxetin,
Xydar,
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Algia,
Unibenestan,
Ketoconazole,
Bactoprim,
Zocin,
Bactox,
Ceftin,
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Clavulin,
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Metabolically active tumor cells with high glucose uptake, as evaluated by a fluorescent glucose analog (2-NBDG), are identified by high-throughput fluorescence screening within a chip containing 200,000 addressable microwells and collected for malignancy confirmation via single-cell sequencing. Degranulation (regulated exocytosis) of crayfish granular blood cells tadalis ajanta pharma viagra and release of the prophenoloxidase activating system can be triggered by two endogenous ligands, a 76-kDa cell adhesion protein or a beta-1,3-glucan-binding protein when reacted with beta-1,3-glucan (beta GBP-L). Non-dystrophic myotonia (NDM) is characterized by myotonia without muscle wasting. The homospecific male pairs never carried each other in the gynaecophoric duct, but they being closed in either central or hepatic veins.
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