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Cycloblastin (Cyclophosphamide)
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Cyclophosphamide

Cycloblastin is a potent immunosuppressant that can decrease the immune response by blocking the production of DNA in cells. Cycloblastin is used for severe complications of lupus, systemic sclerosis (scleroderma), some forms of vasculitis, myopathies, such as polymyositis and dermatomyositis; and sometimes rheumatoid arthritis.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Previous studies showed that an expression level of the C/EBPalpha gene in hepatocytes was downregulated in response to proliferation signals and that forced expression of the C/EBPalpha gene in a number of cells caused cell cycle arrest. The effect may, at least partly, reflect amelioration of radical induced mitochondrial dysfunction. Apart from that, there are wide areas which are solely occupied by smooth endoplasmatic reticulum, whereas other structures, for example fat, are scarely seen.

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Routine MR imaging sequences including enhanced MR imaging showed normal optic nerves, but a diffusion-weighted sequence and apparent diffusion coefficient maps revealed markedly restricted diffusion in the right optic nerve. Relative permeabilities of the lens membranes to sodium and potassium. We report here a new mutation in comparative gene identification-58 (CGI-58) gene causing syndactyly and steatohepatitis induced early cirrhosis. After a slight lag period, a logarithmic increase in cell number was observed through the twelfth day of the culture period. Bovine myeloperoxidase (MPO) was isolated and purified from neutrophil granules using protein extraction at pH 4 and gel filtration combined with fast protein liquid chromatography.

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The aim of this study was to investigate the sexual function of patients with polycystic ovary syndrome (PCOS), including the clinical and hormonal characteristics potentially related to sexual dysfunction, in an endocrinology and gynecology ambulatory. The results demonstrate that normal contractile function of isolated lymphatic vessels can be preserved with long-distance shipping and subsequent overnight recovery if the proper precautions are taken. Mortality in patients with atrial fibrillation has significantly decreased during the last three decades: 35 years of follow-up in 1627 pacemaker patients. Continuous follow-up of surgical site infections for 30 days after colorectal surgery. However, it is still unclear whether the f/t PSA ratio is superior to PSA or PSAD in the discrimination between BPH and prostate cancer in Japanese male patients.

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The duration of discrete capillary obstructions was short and in all cases comparable with that of naturally occurring leukocyte plugging. The management of community-acquired pneumonia (CAP) continues to be a challenge, especially in older people. This report describes 2 cases where a prompt diagnosis of tuberculous peritonitis was made employing the Xpert MTB/RIF assay (Cepheid Inc., Sunnyvale, CA, USA).

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Bendamustine has shown considerable clinical activity against indolent lymphoid malignancies as a single agent or in combination with rituximab, but combination with additional anti-cancer drugs may be required for refractory and/or relapsed cases as well as other intractable tumors. Simulation results show that the proposed empirical likelihood method has better finite-sample performance than other competitors. Early menopause is associated with lack of response to antiviral therapy in women with chronic hepatitis C. Atrial fibrillation (AF) is a multifactorial and multiscale disease, where electrical, structural, anatomical and genetic factors contribute to the emergence of a complex and dynamic macroscopic phenotype.

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Optic properties of some arabinosides (beta-D-arabinofuranosides) We present a quantitative theory and experiments for the expansion dynamics of domains in stratifying foam films. The aim of this study was to test if, by targeting hematopoietic tumors with HRP-conjugated antibodies in association with IAA treatment, there is induction of apoptosis.

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Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiency. These methods are expensive, required special skill and have side effects.

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We find that each of the four carotenoid-containing droplet types consists of a complex mixture of carotenoids, with a single predominant carotenoid determining the wavelength of the spectral filtering cut-off. In three experiments that used levels of processing and study time manipulations as independent variables in a word fragment completion task, the validity of the assumption of independence between recollection and automatic influences of memory was assessed.

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Fetal body weight and the number of male live fetuses were significantly decreased, along with a tendency of the number of intrauterine deaths to increase. Changes in procalcitonin and interleukin 6 levels among treated African patients with different clinical forms of malaria. The results showed that, except in repressed cells, Sck1 probably mediates a cAMP-independent activation of trehalase following the signal(s) triggered by glucose and the nitrogen source. Intrinsic motivation: the dynamics of occupational therapy theory.

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To evaluate the long term effects of perioperative beta blockade on mortality and cardiac morbidity in patients with diabetes undergoing major non-cardiac surgery. Experiences of special gynaecological services for children and adolescents: a descriptive study. Assessment of the nutritional effects of olestra, a nonabsorbed fat replacement: introduction and overview. We sought to determine diagnostic yield and identify factors predicting diagnostic findings in this elderly population. Immunization of horses against rhinopneumonitis (equine virus abortion) with porcine-testicle-cell adapted live virus

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Determinants of villous trophoblastic hyperplasia in spontaneous abortions. CT-guided bipolar and multipolar radiofrequency ablation (RF ablation) of renal cell carcinoma: specific technical aspects and clinical results. ArcLight consists of super-ecliptic (SE) pHluorin (pH-sensitive fluorescent protein) with an A227D substitution, which confers voltage sensitivity in neurons, fused to the voltage-sensing domain of the voltage-sensing phosphatase of C iona i ntestinalis (Ci-VSD).

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Here we report elevated proteins in plasma that function in inflammation and responses to oxidative stress and damaged tissue at 24 hrs post-stressor. Refractory hypercapnia: a simplified technique for extracorporeal CO2 removal (ECCO2R) in the presence of therapeutic limitations.

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Transfusion reaction related to the admixture of aqueous glucose solution and blood. Both LNR and LODDS are superior to the classical nodal status in predicting prognosis in resected pancreatic cancer. In that vein, maintenance therapy is emerging as a new treatment option in the metastatic setting.

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Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal. Aminoglycoside ototoxicity in three murine strains and effects on NKCC1 of stria vascularis. There is no agreement between the RR and RI, which may be owing to the different conditions under which measurements are made.

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We collected cervical and endometrial samples from women using the hormonal intrauterine device to study its effects on endocervical cytokines/chemokine concentrations, phenotypic markers of T cells, responses of endometrial T cells to activation, and alterations of endometrial cellular infiltrates. GOT, GPT and LDH levels were completely normalized by the 21st hospital day. A weak positive correlation has been described between hyperandrogenaemia and obesity in adolescent girls, but the clinical consequences are still poorly understood. Intraocular lens power value in diopters and the magnitude of disparity between an existing individual IOL formula and our super formula. Although carotid intima-media thickness (CIMT) assesses the structural properties of the carotid artery, it does not assess the mechanical properties of the vessel.

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We found that CBC, biochemistry, and serology profiles could be obtained more readily when blood samples were placed in a single lithium heparin tube than in 2 separate tubes. For electrophysiologic testing, the extracellular activity of single neurons was recorded in the ventrobasal nucleus of the thalamus in anesthetized rats. Migration patterns of lung-associated lymphocytes nemasole suspension efferent from the caudal mediastinal lymph node. Insulator-based DEP and light-induced DEP are the most significant examples.

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Scombroid fish poisoning, one of the most common adverse reactions to fish, is also probably one of the most common causes of a flushing syndrome. Templated polymers enable selective gastride drug capture and release of lysophosphatidic acid in human plasma via optimization of non-covalent binding to functional monomers. High-b-value DW-MRI allows detection of colorectal adenocarcinoma with a high sensitivity and specificity. Respiratory chain complexes in mitochondria are assembled from subunits derived from two genetic systems.

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