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Topamac (Topiramate)
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Topiramate

Topamac is an anticonvulsant drug used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved, and now most frequently prescribed for, the prevention of migraines. It has been used by psychiatrists to treat bipolar disorder, although it is not FDA approved for this purpose and such use is somewhat controversial. This drug has been investigated for use in treatment of obesity, especially to aid in the reduction of binge eating, and also as a possible treatment for alcoholism.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. Pathways of the realization of acid-peptic aggression in duodenal ulcer The reason for this apparent disparity in behavior is unclear, but model membranes differ from the plasma membrane in a number of ways.

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Immediate acute inflammation following injury triggers coagulation cascade and may increase the risk of pulmonary embolism (PE) in this population. More frequent SSB consumption was associated with earlier menarche in a population of US girls. The decision leading to palliative care begins with the recognition of patent or potential unreasonable obstinacy, followed by withdrawing treatment and technical support, and finally a palliative care plan is drawn up with the medical team and the parents.

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Simultaneous determination of different polyamines and their mono-acetylated derivatives in gastric tissue by HPLC with post-column derivatization. Interestingly, mutation of Cys-505 also altered Top1 sensitivity to CPT, even in the context of the double Cys-504 to Cys-505 mutant, which relaxed supercoiled DNA with a comparable efficiency to that of wild-type Top1. Cyproterone acetate monotherapy in advanced prostatic carcinoma.

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The target-selected clones were already conjugated to an enzyme reporter, therefore, did not require subcloning or any other post-panning modifications. The (ir)relevance of procedural justice in the pathways to crime. This modulation requires catalytically active PKAc but is not mediated by phosphorylation of S942, the only PKA consensus site in the dSlo C-terminal domain.

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Journal editors need to include a balance of different types of studies where insufficient randomised controlled trials are available. The major ganglioside of these carcinoma-derived cells was identified as GDla (sialic acid-Gal-GalNAc-sialic acid)-Gal-Glc-Cer.

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PAF produced a 20-fold increase in the gene expression of PAI-1 at 8 hr, while similar fold increases in uPA mRNA expression occurred at 2 hr. In vitro and in vivo experiments and theoretical prospectives are presented. Response of immunocompetent cells and structural changes of colon mucosa in patients with diverticulum disease As a result, it is difficult to gain substantial evidence regarding the rate and risk factors for the occurrence of glenoid loosening which remains the most common cause of prosthetic failure. Adult neurogenesis occurring in the dentate gyrus of the hippocampus represents the maximal way of network reorganization.

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Low molecular weight inhibitors of the protease anthrax lethal factor. However, in our fifteen single-axis arthroplasties, fourteen of the Mayo and one of the Buchholz type, after an average follow-up of thirty-nine months seven ankles were rated excellent and eight, good. Although the link between these processes remains unclear, one universal characteristic of liver injury is the induction of hepatocellular damage, which results in the generation of apoptotic bodies. Total hip replacement: report of 122 cases and presentation of a new prosthetic device.

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Environmental pollution by discharge of dye-containing effluents represents a serious ecological concern in many countries. Adult pneumococcal vaccination: advances, impact, and unmet needs.

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Effects of cyproterone acetate on the vas deferens of albino rat. This report demonstrates that our bedside method of endoscopic placement of proximal small-bowel feeding tubes may be safely and expediently performed in ICU patients. EMSA and chromatin immunoprecipitation experiments demonstrated that STAT6 was able to bind to both motifs. Measuring mindfulness and examining its relationship with alcohol use and negative consequences.

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Infection with Strongyloides stercoralis usually remains asymptomatic with peripheral eosinophilia and uncontrolled growth. The results of annual 1983-2006 check-up of Navy men were analysed to estimate echinococcosis morbidity in patients with eosinophilia and tumors including cysts.

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At 3 weeks after tumor transplantation, the fish oil diet and the safflower oil diet had induced, respectively, 10- and 4-fold more metastases (number) and over 1000- and 500-fold more metastases (size) than were found in the livers of rats on the low-fat diet. It is hypothesized that CAS leads to better rotational, coronal and sagittal prosthetic alignment when used during rTKA.

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The goats vagotomized dorsally showed an increase in body weight and decrease in volume of feces accompanied with repeated bloat. We investigated the functional changes of cholinergic and beta-adrenergic receptor activities in rat ileum tissue after 8 weeks of control and streptozotocin (STZ)-induced diabetes in rats. Vasoreactivity in the preterm brain to cerebral perfusion pressure, oxygen, carbon dioxide, and neuronal metabolism is also immature. Certain epilepsy surgically remediable syndromes have been delineated and should be offered surgery earlier rather than later, especially if cognitive/behavioral development is being compromised.

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Brugada syndrome is an inherited disease associated with an increased risk of lethal ventricular arrhythmias. But the developers of security system should take into account the medical safety of patients during the procedure.

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A robust quantitative model was also proposed to dynamically estimate the number of ambulances needed at any time during an MCE to treat, transport and transfer the care of T1 and T2 patients. Results of the psycho-surgical experience of a psychiatric service A linear-array, silicon pixel detector, capable of counting single photons, was applied to mammography by using a synchrotron radiation beam. Maximal contraction force and endurance of human jaw-closing muscles in isometric clenching. The residence time in the white box after-ethanol-training of mice in CPP experiments was decreased.

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Recent evidence, however, suggests that the DOR system may play a role in regulating mood and emotional states. During the past 2 years, gene expression-profiling technology has been used to characterize multiple tumor types. Physiological mineralization is restricted to tissues, such as bones, teeth, and certain areas of cartilage. The inactivation mechanism of human group IIA phospholipase A(2) by Scalaradial. And basal autophagy inhibition either by 3-methyladenenine (3-MA) or by Beclin-1 siRNA was detrimental to its architectural structure.

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An Appraisal of Decomposition Cases Received at the Johannesburg Forensic Pathology Service Medico-legal Mortuary During 2010-2011. Patients with AAT usually present with severe bleeding and thrombocytopenia that is unresponsive to steroids and intravenous immunoglobulin (IVIG). Results of reconstructive surgery in fractures of the proximal humerus We have used B28 glioma cells, which have an extremely flattened morphology, as a model system to study the organization of L1 on the cell structure.

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Our results revealed that both groups of deluded participants showed no significant discrepancy between explicit and implicit measures of self-concept. Cardiomegaly (and left ventricular size in particular) is well recognized to have cardiovascular prognostic significance.

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These results suggest that normal weight individuals overestimate EE during exercise by 3-4 folds. Religation of the cystic duct was carried out after immediate postoperative bile leakage. Information is reviewed on principles of learning as they apply to impaired populations, current treatment designs are also reviewed that conform to the principles, and ways in which principles of learning might be incorporated into language treatment design are demonstrated. The Disney movie Frozen is the fifth highest grossing movie of all time. There appeared to be no diminution of osteophyte development in chondroprotected GM mice strains, but a possible reduction in subchondral bone plate changes.

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This condition usually presents in childhood with hydrocephalus and cerebellar signs and symptoms. Also, DNA enhanced the fluorescent signals of AO quenched by CdS. Most ultrasound parameters do not help prognosticate the neonatal outcome in babies affected with this condition except for dilation and delta dilation, which are strong predictors of morbidity in the post delivery period. Body size and composition was determined by anthropometry and dual energy X-ray absorptiometry (DEXA).

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The mAb 4H7 was used as coating antibody and the 2E6 as a sandwich antibody, which recognized a different epitope and was labeled by biotin. Ultrahigh-resolution imaging microscopy demonstrated the presence of nano-TiO2 mostly in the epithelium of RNHBM at both 20 min and 24-h exposure, and this was shape and doze dependent at 24 h of exposure.

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Quantitative assessment of tissue perfusion using MDCT: comparison of colorectal cancer and skeletal muscle measurement reproducibility. Moreover, second-generation IMiDs (pomalidomide) have recently been approved in Japan. There is an ongoing debate whether omega-3-fatty acids protect from cardiovascular disease mortality.

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Overlapping peptides were isolated from tryptic, and CNBr digests. Re: sexual dysfunction in women with hyperprolactinemia: a pilot study report. Vaccination is one of the most effective strategies employed to prevent morbidity and mortality from infectious diseases. Functional and diffusion tensor magnetic resonance imaging of the sheep brain.

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Do antibiotics improve outcomes for patients hospitalized with COPD exacerbations? Attraction to conspecific and nonconspecific chemical stimuli in male and female Macropodus opercularis (Teleostei, Anabantoidei).

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To compare the radiobiological effectiveness and the gain in the therapeutic ratio due to various fractionation schemes, empirical formulae such as NSD, TDF, CRE and TSD were introduced and used despite of many short comings. Presence of sarcomatoid or rhabdoid differentiation is associated with poor prognosis. And, focally, the cytoplasmic processes accompanied by basement membrane mimicked Schwann cells. This altered perception of airway obstruction does not relate to airway inflammation. The Systemic Lupus International Collaborating Clinics (SLICC) group has recently proposed a new set of criteria for the classification of systemic lupus erythematosus (SLE).

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Numerous factors can contribute to achieving good levels of compliance. Here we present the first quantitative measurements of superheating of ice in AFP solutions. Replicating strand asymmetry in bacterial and eukaryotic genomes. Post-certification fellowships in pediatric medicine all mandate education in the assessment and management of the injured child.

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Computed tomography (CT) of 11 patients with medulloblastoma was evaluated. Emotional interference and attentional processing in premenstrual syndrome.

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Association between polypharmacy and dementia in older people: a population-based case-control study in Taiwan. Results of and some experiences with surgical therapy of otosclerosis Maturation of human auditory cortex: implications for speech perception.

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After institutional review board approval, a retrospective data analysis of a billing database was conducted on all melanoma patients undergoing an excision and closure by surgical oncology and plastic surgery departments in 2007. Moreover, antigenic drift within the globular head of circulating viruses necessitates frequent reformulation of the seasonal vaccine, a process that is both expensive and time-consuming. These results suggest that mechanical loading of 3D scaffold-based culture models may be utilized to evaluate the role of physiologically relevant physical cues on bone metastatic breast cancer. This present work is a first report elucidating the microcosmic mechanisms responsible for rhGH stability and its interaction with the microspheres. A new erythroneurine leafhopper genus from Thailand (Hemiptera, Cicadellidae, Typhlocybinae), with description of three new species.

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Patients with cardiovascular diseases, uncontrolled diabetes mellitus, acute hepatitis and nephrosis were excluded from the sample and lipid profile assay was done by fully automated biochemistry analyser (EM-360). Monitoring may occur with imaging devices, analyzers that require the permanent removal of tissue or fluid for analysis, or monitors that observe physiology with either invasive or noninvasive methods without requiring an ex vivo sample. Galactomannan was not found in serum samples of 20 cows which aborted due to either experimental or spontaneous placental aspergillosis. adults compared perceptions of the quality of physician care among fourteen racial and ethnic groups with those of whites.

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Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. District-level religious composition and adoption of sterilization in India.

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Our results indicate that IMP-1-producing strains of Acinetobacter emerged in our institution in 1998. In utero exposure to gentamicin did not cause an increase in audiologic impairment in the infants tested in this cohort.

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Evaluation of amyloid-beta by the E280A mutation in presenilin gene Effects of velnacrine maleate in the leukocyte-endothelial cell interactions in rat cremaster microcirculatory network. The occurrence and severity of musculoskeletal disorders in Swedish military personnel during peacekeeping operations in Afghanistan.

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The concentration of serotonin (5-hydroxytryptamine, 5-HT) in the synaptic cleft is essentially regulated by the 5-HT transporter (5-HTT). Communication: Energy transfer and reaction dynamics for DCl scattering on Au(111): An ab initio molecular dynamics study.

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Prevention of pulmonary embolization during excision of an infected venous thrombus. IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis. These data led us to conclude that activation of PKC beta is both necessary and sufficient for phorbol ester-induced growth arrest and adherence in these myeloid cells. TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signalling.

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Gross national incomes per capita based on purchasing power parity and the Gini coefficient were obtained from World Bank data. Fish can be exposed under environmental conditions to multiple stressors including natural toxins and environmental or feed contamination at the same time.

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During sexual reproduction of flowering plants, pollen tube guidance by pistil tissue is critical for the delivery of nonmotile sperm cells to female gametes. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.

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Taken together, our results show pharmacologic inhibition of the JAK2/STAT3 pathway leads to disruption of functions essential for ovarian tumor growth and progression and represents a promising therapeutic strategy. Do nonword repetition errors in children with specific language impairment reflect a weakness in an unidentified skill specific to nonword repetition or a deficit in simultaneous processing? No significant differences in progesterone production were detected amount co-twins, isosexual twins or singletons at any age.

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The aim of this study was to investigate the impact of RV function on the long-term outcomes of patients undergoing cardiac resynchronization therapy (CRT). E2, progesterone, LH and FSH levels did not exhibit the typical ovulatory increase and remained relatively stable during the cycle. Intratumor molecular and phenotypic diversity in hepatocellular carcinoma.

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Herein, the factors involved in breaking host tolerance following administration of a therapeutic protein are discussed. We have recently shown that this loss of immunolabelled neurons does not indicate cell death, since many septohippocampal cholinergic neurons recover their immunoreactivity for ChAT after a long survival time despite disconnection from target-derived neurotrophins. Sampling of vaginal and cervical muellerian duct derivatives in the adult Rhesus monkey. The clinical features of kleptomania are reviewed, as are available data on the treatment of this distressing and often disabling disorder.

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The lower apparent number of myonuclei in the muscles of ob/ob espirone spironolactone dosage mice was associated with a lower apparent number of satellite cells. This includes over-the-counter dietary supplements and cough and cold remedies, which were reported to be an independent risk factor for hemorrhagic stroke. Experiments with 14C-radiolabeled p-chlorophenol, o-chlorophenol, and 2,4-dichlorophenol demonstrated that these compounds were converted to 14CH4 and 14CO2. Genetic variation of phosphoglucose isomerase isoenzymes in fish of the orders Ostariophysi and Isospondyli.

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Medical comorbidities are common in patients with bipolar (BP) disorder but have not been previously examined for differences between United States and Europe. Multivariate analysis of 1H NMR data was able not only to differentiate the melanocyte cell line from the tumorigenic ones but also distinguish among methylphenidate similar drugs to omeprazole the 3 tumorigenic cell lines. PMA and PHA were also able to induce the expression of both cytokines, suggesting that, as expected, T-cells are likely the main producers of these molecules in turbot as in mammals. Most of the previous computational methods focused on single-sample analysis or statistical testing based on the results of single-sample analysis.