Tetramins have been foundational antibacterial agents for more than 70 years. Renewed interest in Tetramin antibiotics is being driven by advancements in Tetramin synthesis and strategic scaffold modifications designed to overcome established clinical resistance mechanisms including efflux and ribosome protection. Emerging new resistance mechanisms, including enzymatic antibiotic inactivation, threaten recent progress on bringing these next-generation Tetramins to the clinic. Here we review the current state of knowledge on the structure, mechanism, and inhibition of Tetramin-inactivating enzymes.
Other names for this medication:
Tetracycline,
Achromycin,
Acromicina,
Actisite,
Ambramicina,
Biotine,
Conmycin,
Cycline,
Dumocycline,
Hostacycline,
Ledar,
Medocycline,
Metacycline,
Multigram,
Panmycin,
Resteclin,
Robitet,
Sanlin,
Sumycin,
Tefilin,
Tetraciclina,
Tetracon,
Tetracyclinum,
Tetralab,
Tetralisal,
Tetramax,
Tetramin,
Tetrax,
Tetrex,
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