on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)


Tenofovir oral powder is available for oral administration as white, taste-masked, coated granules containing 40 mg of Tenofovir DF per gram of oral powder, which is equivalent to 33 mg of Tenofovir disoproxil. The oral powder contains the following inactive ingredients: mannitol, hydroxypropyl cellulose, ethylcellulose, and silicon dioxide.

Other names for this medication:
Tenofovir, Atripla, Tenvir, Trioday, Truvada, Viraday, Viread,

Similar Products:
Motivan, Vilitra, Cycline, Acipan, Aramix, Avertex, Biomoxil, Klabet, Finasteride, Turresis, Darunavir, Pegetron, Estiva, Ogasto, Sofab, Bactropin, Aclav, Tricef, Orvagil, Kenazol, Helicol, Uroxal, Quetiapin, Espram, Sizodon, Elequine, Pantecta, Omecip, Akorazol, Omepradex, Blistex, Flunil, Omig, Amosine, Elafax, Quantrum, Filmet, Klont, Amoxival,

mechanism tenofovir nephrotoxicity symptoms

To report a case of hypertrophic cranial pachymeningitis (HCP) associated with the long-term administration of nonsteroidal antiinflammatory drugs (NSAIDs). Variations in renal threshold for glucose in Type 1 (insulin-dependent) diabetes mellitus.

caprisa tenofovir gel trial

parthenogenetica over a range of salinities during a week, before transferring them to a (possibly) different salinity for the rest of their lives. Each case of SCT was defined as complicated or uncomplicated based on the postnatal outcome.

efavirenz lamivudine tenofovir tablets walmart

Another possibility is that specific methylation marks that are environmentally-induced, yet non-heritable, could influence preferential survival and lead to consistent methylation of the same genomic regions over time. Activation of cytokines corroborate with development of inflammation and autoimmunity in thromboangiitis obliterans patients. The current situation and thoughts of cardiovascular disease in chronic kidney disease

tenofovir lamivudine efavirenz fixed dose combination products

The functional and aesthetic problems caused by this pathology are analyzed. Assuming that liberation of algogenic substances is important, the question arising is: if tender muscle points are not the primary sites of on-going neurogenic inflammation, which structure can be responsible for liberation of chemical mediators in the periphery? Finally, a whole ovarian culture system using neonatal mouse and rat ovaries has been developed to expand the potential for more in depth investigations into ovotoxicity caused by VCD. Hereditory spherocytosis is uncommon in Malay population and presentation with jaundice of 20 years duration with leucoerythroblastic picture on blood film were interesting features in this case. The data collectively indicate that the control of the synthesis of ZnBP which occurs at the transcriptional level of protein synthesis is responsive to zinc status and thus may have a function in zinc metabolism.

tenofovir disoproxil fumarate tablets monograph meaning

The effect of such gradient fields on the relationship between the desired excitation profile and the corresponding radiofrequency pulse is shown. Optical waveguide switch (3 x 3) for an optical switching system.

tenofovir dose in renal impairment classification

Randomized trials face a lot of drawbacks, including ethical issues. Every organism has a minimal requirement of each metal based on the intracellular abundance of proteins that use inorganic cofactors, but elemental sparing mechanisms can reduce this quota. Further controlled clinical studies are needed to clarify aspects of this statement, and revision may be necessary as new data appear. To the best of our knowledge, so far, only 13 cases have been reported of tumors that histologically show features of amelobalstoma and AOT with hard tissue formation. Gestational diabetes mellitus (GDM) reflects defects in insulin secretion in response to the metabolic demands of pregnancy.

tenofovir gel trial

Genomic analysis of pediatric cataract in Saudi Arabia reveals novel candidate disease genes. We describe a patient with diabetic nephropathy who developed septicemia with metastatic abscesses in the liver and spleen due to Moraxella lacunata. Long-term follow-up study of uncertainty and psychosocial adjustment among implantable cardioverter defibrillator recipients. To evaluate the robustness of the proposed approach in noisy environment, we add different types of noise and different amount of noise to T1-weighted brain MR images. rSO(2) showed a quick recovery to baseline values, but the aEEG-measured electrocortical brain activity remained reduced following HI.

tenofovir disoproxil fumarate tablets iphone

pertussis vaccine as adjuvant had no qualitative effect upon the response. The burden of nutritional problems is shifting from energy imbalance deficiency to excess among older children and adolescents in Brazil and China. strain A9 is an important bioflocculant-producing bacterium, isolated from a soil sample, and is pale pink-pigmented, aerobic, and Gram-positive. Nongenotoxic activation of p53 using nutlin led to a reversible activation of G1 and G2 arrest in normal cells, which prevents them from entering mitosis, thus protecting them from the side effects of aurora kinase inhibition (VX-680), namely endoreduplication and apoptosis. We conclude that the changes in synaptic plasticity and many other signaling events that occur in response to AMPH sensitization are dissociable from those involved in learning the tasks used in our experiments.

efavirenz lamivudine tenofovir tablets

Quantitative evaluation of aggregated lymphoid follicles in various compartments of the large intestine was carried out in Wistar rats of different age: newborn (3-4 days), prepubertal (20-30 days), adult (2-3 months), and old (16-18 months). We present a case of an 84-year-old female with prior CABG and severe PAD who underwent transapical TAVR for severe symptomatic AS sustaining an acute myocardial injury from damage to her apical epicardial collateral circulation. In this study, we evaluate the safety impacts of changing left-turn signal phasing from permissive to protected/permissive or protected-only at 68 intersections in New York City using a rigorous quasi-experimental design accompanied with regression modeling. The comet optical density values are used to quantify the total comet fluorescence and hence indicate DNA content and the level of damage.

tenofovir gel and sirna nano particles for drug

Additionally, synchronous acquisition spectra of the central and satellite transition resonances can be separated by different projections of the TOP spectrum, with higher resolution spectra often found in the satellite transitions projection. Relationships between baby feeding types and patterns, gut transit time of meconium and the incidence of neonatal jaundice. Physicians concluded the cause of cholecystitis as gall bladder (GB) stone and proper antibiotics treatment of scrub typhus was started later. Although few studies have evaluated the pediatric and adolescent population, arthroscopic surgical repair remains the standard of care for patients in this age group with unstable meniscal tears. The present report, the first of it kind in Ethiopia describes a case of veno-occlusive liver disease in a 12-year old Ethiopian boy.

fanconi syndrome tenofovir cost

Esomeprazole, given as a continuous high-dose intravenous infusion followed by an oral regimen after successful endoscopic therapy for PUB, was well tolerated, with no apparent safety concerns from either the high-dose intravenous treatment or oral phases. Significance of parietography in the differential diagnosis of polyp-like growths on the gastric mucosa Experiments to test whether HCE exhibited inhibitory activity led to an unexpected result: When added to human serum dilutions, HCE caused a significant, dose-dependent increase of C-activity. Prior pharmacogenetic studies usually measure exposure via single plasma levels, examine limited numbers of polymorphisms, and rarely model multiple contributors.

etravirina tipranavir tenofovir lamivudina efavirenz package

Atypical clinical and morphological presentations may have lead to pretherapeutic biopsies of the pancreatic mass in order to indicate primary chemotherapy. The predictor variables were grouped into demographic, medical, radiographic, and operative categories. When compressed and mounted on the balloon catheter, the stent is flexible. If giant cell arteritis causes blindness in one eye there is significant risk for the other eye to go blind if no treatment is given.

tenofovir gel 1 injections

Exaggerated startle response is a prominent feature of posttraumatic stress disorder (PTSD) although results examining differences in the acoustic startle response (ASR) between those with and without PTSD are mixed. Cardiac index increased from 4.04 plus or minus 0.62 1/min/m-2 before TCH to 6.92 plus or minus 2.34 1/min/m-2 after 134 mug/kg.

lamivudina tenofovir y efavirenz package

DNA Methylation Profiling in Chondrocyte Dedifferentiation In Vitro. A technique for analysis of dynamic radionuclide studies of the cerebral circulation is described. The aim of this study was to clarify the timing of injuries in utero that cause respiratory inhibition after crying (RIAC). The power of the proposition: frequency of marijuana offers, parental knowledge, and adolescent marijuana use. In contrast, functional abrogation of two receptor binding sites showed a strong decrease in both, affinity and bioactivity on TNFR2-Fas.

tenofovir gel for men

  • tenofovir dose for hep b
  • tenofovir side effects medscape psychiatry
  • tenofovir hepatitis b review
  • tenofovir dose reduction and discontinuation
  • fanconi syndrome caused by tenofovir mechanism
  • tenofovir disoproxil fumarate usp monograph calcium
  • tenofovir hepatitis b nejm image
  • gel microbicide tenofovir package
  • interaction between atazanavir and tenofovir alafenamide
  • tenofovir nephrotoxicity incidence versus
  • tenofovir disoproxil fumarate generic cymbalta
  • tenofovir alafenamide vs tenofovir disoproxil fumarate side
  • tenofovir dose for hbvl
  • tenofovir gel wikipedia
  • emtricitabine tenofovir tablets information security
  • tenofovir hepatitis b cure
  • tenofovir hepatitis b cure rates
  • hep b treatment tenofovir mechanism
  • tenofovir disoproxil fumarate pro drugs
  • emtricitabine 200mg/tenofovir 300mg tab
  • tenofovir gel and sirna nano particles synthesis
  • tenofovir disoproxil fumarate tablets ipod
  • tenofovir missed dose of coumadin
  • tenofovir dose hepatitis b
  • tenofovir disoproxil fumarate tablets monograph definition
  • tenofovir disoproxil fumarate dose response
  • tenofovir alafenamide mechanism of action
  • tenofovir and emtricitabine truvada price
  • how to pronounce tenofovir cost
  • tenofovir missed dose of effexor
  • gel microbicide tenofovir
  • emtricitabine tenofovir brand
  • tenofovir dose reduction factor
  • side effects of tenofovir disoproxil fumarate
  • mechanism tenofovir nephrotoxicity treatment
  • efavirenz lamivudine tenofovir tablets with keyboards
  • emtricitabine tenofovir nevirapine syrup
  • fanconi syndrome tenofovir--understanding proximal tubular function
  • tenofovir price in pakistan n8
  • hep b treatment tenofovir dosage
  • tenofovir price in pakistan lt600
  • tenofovir disoproxil fumarate dose of colors
  • tenofovir price in pakistan of anti
  • tenofovir dose in dialysis what flows
  • baraclude vs tenofovir price
  • microbicide tenofovir cost
  • efavirenz lamivudine and tenofovir tablets with usb
  • tenofovir gel for men
  • tenofovir gel side effects
  • tenofovir lamivudine fixed dose combination definition
  • tenofovir package insert pdf into pdf
  • fanconi syndrome tenofovir cost
  • tenofovir disoproxil fumarate lamivudine efavirenz drugs
  • fanconi syndrome tenofovir side
  • tenofovir missed dose of lexapro
  • tenofovir disoproxil fumarate generic zyrtec
  • tenofovir gel study
  • tenofovir pronunciation of biblical names
  • emtricitabine and tenofovir disoproxil fumarate tablets usp monograph
  • rilpivirine versus efavirenz tenofovir emtricitabine rilpivirine
  • tenofovir disoproxil fumarate metabolism pills

lamivudine tenofovir disoproxil fumarate nevirapine dose

Both larger molecule removal and dialyzer biocompatibility have been implicated in the high-flux hemodialysis (HD)-associated favorable outcome. Parameters affecting lithium acetate-mediated transformation of Saccharomyces cerevisiae and development of a rapid and simplified procedure.

tenofovir dose for hep b

The goal of this study was to investigate the immunogenic and functional properties of the fusion (F) and attachment (G) glycoproteins of NV. These DNA repair abnormalities have the potential to affect a number of processes such as genomic instability and therapy response, and the consequences of these defects deserve further study in EAC. Repetitive transcranial magnetic stimulation (rTMS) is a well-established technique for non-invasive cortical stimulation.

tenofovir lamivudine efavirenz tablets 600

Cutaneous involvement was present in 3 patients, hematologic involvement in 2 patients and gastrointestinal involvement in 2 patients. In synthetic biology, metabolic engineering, and gene therapy, there is a strong demand for orthogonal or externally controlled regulation of gene expression. This technique allows us to have one study lung and one control lung. 3) The correlation coefficients of cholesterol between parent and child and between siblings were found to be 0.26004, 0.27998, respectively.

tenofovir gel purchase

A subset of pancreatic ductal adenocarcinomas (PDACs) is characterized by EGFR gene numerical alterations including sporadic cases of amplification or absence of one allele (maybe due to gene deletion or intragenic point mutation and allelic silence). Results suggest that the high proportion of SoFAS in each recommended food group makes it challenging for Americans to reduce their intake of SoFAS. Results show that the contribution rate of economic output and energy structure to energy-related carbon emissions increases year by year. Recent trails and meta-analyses have demonstrated that amiodarone is the most antiarrhythmic drug currently available.

cure for hepatitis b 2012 tenofovir price

Few articles were found that directly pertained to athletes, therefore, the review additionally characterizes literature found in a non-athlete population. According to this, it is a future challenge to anchor guideline-based diagnostics and treatment in routine care.

emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg tablets

The pLVD of PC was significantly higher than that of SPTP and CP, but there was no difference between SPTP and CP. Incidence and long-term follow-up of silent cerebral lesions after pulmonary vein isolation using a remote robotic navigation system as compared with manual ablation. A rapid infusion pump driven by micro electromagnetic linear actuation for pre-hospital intravenous fluid administration. Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction.

baraclude vs tenofovir

Comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver. Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population.

tenofovir and liver toxicity rash

There is an ongoing search for immunosuppressive regimens that provide adequate protection against all patterns of xenograft rejection, but have no severe impact on the condition of xenograft recipients. Driven by promising experiences with the first marketed complement drugs, increased knowledge about the involvement of complement in health and disease, and improvements in structural and analytical techniques as well as animal models of disease, the field has seen a surge in creative approaches to therapeutically intervene at various stages of the cascade. Deletion or duplication of 15q11-13 GABR genes occurs in multiple human neurodevelopmental disorders including Prader-Willi syndrome (PWS), Angelman syndrome (AS) and autism.

tenofovir missed dose of zoloft

Cancer-to-cancer metastasis: amelanotic melanoma into renal cell carcinoma Despite intensive topical treatment, recourse to parathyroidectomy is often necessary. We observed perturbed barrier function in Mal(-/-) mice, as indicated by reduced electrical resistance and increased mucosa blood permeability following infection.

capriza 004 tenofovir gel herpes

pacificus ticks collected from 25 counties throughout the state. SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR. Although lidocaine spray applied to the perineum during spontaneous vaginal delivery did not reduce perineal pain, it was acceptable to both the women and the midwives. Rapid accumulation and disappearance of plasma membrane proteins during development of wild-type and mutant strains of Dictyostelium discoideum. Spontaneous rupture of the ureter as the primary symptom of malignant lymphoma

pericoital tenofovir gel

Inhibition of the MMPs, therefore, may be a prospective mode of therapy for such lesions. Its expression has been linked to diverse cellular processes such as cell-cycle progression, differentiation or apoptosis. Hypervolemia in dialysis patients--Doppler echocardiography studies.

tenofovir disoproxil fumarate dose response

We compare the financial and psychological costs of elective surgical orchiectomy vs. We propose that lola is necessary for complete chromatin condensation which occurs during programmed cell death in the ovary. Our work identifies a central role for mitochondria in PC degeneration in SCA1 and provides evidence for the supportive use of mitochondria-targeted therapeutics in slowing down disease progression.

k65r tams and tenofovir dosage

The prosocial neuropeptide oxytocin may affect the olfactory system when administered intranasally to humans and there is growing interest in its therapeutic potential in schizophrenia. Effect of temporarily increased ionic strength and of urea on stability of DNA complexes with native and acetylated BPTI. Internal tobacco industry research and marketing documents obtained through court disclosure contained in the Legacy Tobacco Documents Library were searched using keywords related to pack shapes, sizes and opening methods. The t-test was used to compare mean scores, and a linear regression model was used to determine the association of NURRC access on score delta after adjustment for pretest type and resident type.

baraclude vs tenofovir alafenamide

Fluorescence measurements with the glutamate biosensor intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) conditionally expressed in On-Off DSGCs showed that glutamate release in both On- and Off-layer dendrites lacked DS, whereas simultaneously recorded excitatory currents showed apparent DS. Rats reared in isolation were hyperactive to a novel environment and showed shorter retention latencies in the passive avoidance test. This paper presents the first results of a two-stage psychiatric population survey, which uses a new method of directly evaluating needs for specific psychiatric treatment and the extent to which they have been met.

cure for hepatitis b 2012 tenofovir resistance

Heart insufficiency in a newborn with congenital intracranial arteriovenous fistula The level of LDH activation under the influence of the eggs and embryos extracts subjected to the insulin action was decreased. Participants receive unique sets of letter-color pairs based on their pre-existing preferences for colored letters. The performance under shock conditions is similar to that in other studies in which visual and auditory stimuli are presented at the completion of component schedules. State-specific variations in prevalence may reflect differences in population composition, socioeconomic factors, state laws enacted to discourage high-risk behaviors, levels of effort to screen for certain diseases and physiological conditions, and other factors.

lamivudina tenofovir e efavirenz and pregnancy

Lactobacillus reuteri CRL1098 soluble factors modulate tumor necrosis factor alpha production in peripheral blood mononuclear cells: involvement of lipid rafts. Transthyretin amyloidosis (ATTR) is a heterogeneous disorder with multiorgan involvement and a genetic or nongenetic basis. Coherent population trapping spectroscopy of Rb atoms using the phase-locked beams resulted in a spectrum as narrow as that of the case using direct modulation by a stable frequency synthesizer. A good fit for the whole matrix, including the off-diagonal elements, is obtained when we compensate for the birefringence of the rutile particles by performing the computations for spheroids with a slightly larger length/width ratio than measured.

how to pronounce tenofovir price

Lifestyle behavior change and repeat health risk appraisal participation: a structural equation modeling approach. The effect of L-arginine supplementation on natural killer and lymphokine-activated killer cell cytotoxicity and serum levels of the cytokines interleukin-1 beta and 2, interferon-gamma, and tumor necrosis factor-alpha were also measured. After comparing the features of our model with those of real protein-protein interaction networks, we believe that our model can provide relevant insights into the mechanism underlying the evolution of protein-protein interaction networks. These new developments underscore the importance of future research toward understanding the molecular bases of chromosomal fragile sites, including mechanisms involved in DNA strand breakage and repair, chromosomal translocations, and deletions, which may, in turn, provide important new insights into genomic plasticity and neoplastic transformation.

 Show Hide 
dosering tenofovir gel 2012-08-14

Remarkable differences in telomere lengths among cloned cattle derived from different cell types. This is due to unidirectional energy transfer by the excitation of spin-wave modes without time-reversal symmetry and to the conversion of spin waves into heat. Although in our opinion this result was slightly disappointing from a purely functional point of view, they can improve the cosmetic result and continue to be considered in cases in which avoidance of surface irregularities is a primary concern or as a preventative measure in rhinoplasty patients at risk for post-operative precio lansoprazole generico riverdale valve collapse.

tenofovir disoproxil fumarate tablets monographics 2017-04-16

Laryngopharyngeal Reflux (LPR) is a commonly occurring and recently described clinical entity due to the retrograde flow of gastric contents into the pharynx. We have transplanted this neo-stomach as a substitute for the original native stomach in a rat model and confirmed functional adaptation. Preoperatively, all patients presented with thoracic and lower back pain gimaclav suspension 2003 and nine patients with a paraparesis (Frankel grade C).

cipla tenofovir side effects 2018-01-30

We found poor knowledge, a fair attitude and suboptimal practices among the participants. TRAP-stimulated platelet activation, collagen-induced platelet activation and thrombus growth was unaffected by NO inhalation. The methods are compared with respect to their capability to discriminate between celluloses and batches, and with respect to ease and feasibility of sample preparation. Therefore, we propose that the L12P substitution reduces the flexibility of the N-terminal arm, preventing an interaction of AR1 with RNA-P that is essential for activation of the cotC promoter. Predictability of cluvax forte ovulos para que sirve metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.

efavirenz lamivudina y tenofovir price 2019-09-25

This study compares the influence of estrogen, raloxifene and tamoxifen on factors that affect endothelial function in ovariectomized (OVX) rats. Electronic databases and online sites, including PubMed, Cochrane Library of Systematic Reviews, and UpToDate, were used to search for relevant articles and case reports on the use of ECT in patients with and without metallic implants in the head (1964 to 2009). cipmox 500 dosage of amoxicillin A segment of cervical tracheas (six rings) was harvested as an autograft and implanted heterotopically into the greater omentum.

tenofovir gel 1 for arthritis 2013-07-08

Overweight women with type 2 diabetes treated by oral medications who could walk for exercise were eligible. Past studies show physicians have had limited oral health training. First metatarsophalangeal joint motion in Homo sapiens: theoretical association of two-axis kinematics and specific morphometrics. It has been fluconazole pill identification investigated previously in a variety of ways, with the conventional focus being on the children themselves.

cure for hepatitis b 2012 tenofovir viread 2017-01-11

In our experiment, we varied the density of male and female Leptinotarsa decemlineata (Colorado potato beetles) by placing different numbers of the two sexes on enclosed Solanum tuberosum (potato plants) to determine the proportion of females fertilized after 3 or 22 hours. These epitopes are present not only in bacterial cell walls, but also in common environmental allergens. When should physical rehabilitation commence after stroke: a systematic review. Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. These results suggest that a selective killing of esophageal tumor cells ranitidine 300 mg bdi is directed by G-rich ODNs.

tenofovir disoproxil fumarate pro drug design 2017-12-09

This article describes how the main clinical problems are handled in the elderly with hip fractures in our hospital, based on recommendations of the main guidelines and publications. Although theatrical activities are used in a variety of therapeutic settings, little attention timonil 300 retard cena vs lesnar has been paid to the ways that theater can enhance the recovery process and community integration for people living with psychiatric disabilities. Clinical and endocrinological evaluation of response to treatment. We present two parametrizations for use with experimentally determined (Surface-SFED/HB(exp)) and empirical (Surface-SFED/HB(cal)) hydrogen bond acidity and basicity values. Since amplification seems to be a primary aberration in these tumors, whereas amplification in osteosarcoma generally is a progression marker, the underlying biological mechanisms may be different.

tenofovir alafenamide phase 3 clinical trials 2013-11-15

Patients underwent surgery and conventional colonoscopy, and surgical histopathological correlation was obtained. Diabetes mellitus (diabetes) is associated with significantly increased risk wormex worm syrup of peripheral vascular disease.

birinapant and the antiviral drug entecavir vs tenofovir 2011-01-28

However, the increase in the market price for gold during the first decade of the 21st century and into 2011, and advances recorded for the gold concentration and biomass yield of a range of plant species, suggest that gold phytomining might be an economically viable technology. The methods lipophage capsules nespresso employing a fused-silica capillary and normal polarity mode provided good resolution of substrates and products of the enzymatic reaction and a short analysis time of less than 10 min.

rilpivirine versus efavirenz tenofovir emtricitabine rilpivirine 2015-02-16

Ageing zenpro audio review mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. Clinical follow-up was performed on all subjects by clinic visit or telephone interview. BALB/c mice were sensitized to and challenged with ovalbumin (OVA).

abcc2 tenofovir package 2015-07-09

The scenes differed along five two-valued dimensions (site, weather, camera distance, camera orientation, and camera height), and all combinations of the feature values were used. In response to an isoenergetic change from a high-carbohydrate to HFD, higher carbohydrate balance related to increased energy intake. Most cancer cefuroxime drug study nursing responsibilities for insulin patients suffer urological cancer-related and postoperative complications. Usefulness of AgNOR technique and CEA expression in atypical metaplastic cells from cervical smears. Effect of substitution on transport and isozyme specificity of p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)-o-chlorophenoxyacetamido-benzenesulfonyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase.