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Gene amplification is thought to promote over-expression of genes favouring tumour development. Structural basis of the inhibition of Golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions. The basic nature of ethical problems experienced by persons with acquired immunodeficiency syndrome: implications for nursing ethics education and practice. The first step in the diagnosis of a metastatic brain lesion is to exclude a primary central nervous sytem tumour, followed by verification or identification of the primary tumor site, in order to guide the clinician to specific therapy.
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